Here we show that subcutaneous Bacillus Calmette–Guérin (BCG) vaccination can induce memory alveolar macrophages (AMs) and trained immunity in the lung. Although parenteral …

In this study, we provide a mechanistic basis for the suppression of MHC-II in BCG infected APCs and suggest an approach to avoid immune-suppression during vaccination. MHC-II molecules …

2020年1月3日 · In order to identify mycobacterial antigens bound to MHC, we have immunoprecipitated MHC class-I and class-II complexes from THP-1 macrophages infected …

2019年8月5日 · BCG evades phagosome maturation, autophagy, and reduces MHC-II expression of antigen-presenting cells (APCs) affecting T-cell activation. To bypass these defects, an …

2025年1月1日 · Bacillus Calmette-Guerin (BCG) is administered to approximately 130 million children every year to protect against Mycobacterium tuberculosis (Mtb), the causative agent …

2024年10月24日 · The current study demonstrates, for the first time, the isolation of BCG derived peptides from class I and class II MHC molecules of professional antigen-presenting cells …

2024年6月18日 · Here, we discover that macrophage MR deficiency impairs the antimycobacterial immune response in BCG-vaccinated mice. Mechanistically, macrophage MR triggers JAK …

BCG avoids lysosomal fusion in macrophages decreasing peptides required for activating CD4 T cells and Th1 immunity while suppressing the expression of MHC-II by antigen presenting …

The only licensed vaccine against tuberculosis (TB), bacille Calmette–Guérin (BCG), protects against severe extrapulmonary forms of TB but is virtually ineffective against the most …

2021年1月25日 · To initiate an early immune response, antigen processing of APCs regulated by internalized BCG 148 enhances the surface expression of MHC-II and intercellular cell …