2022年12月9日 · We demonstrated significantly enhanced brain exposure of therapeutic antibodies using optimal transferrin receptor or CD98 TEMs. We found that these modules also mediated efficient clearance of tau aggregates and HER2+ tumor cells via a non-classical phagocytosis mechanism through direct engagement of myeloid cells.

2023年5月25日 · Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence...

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血液和脑组织之间，有选择性通透的屏障结构，称为 血脑屏障（blood-brain barrier，缩写为BBB）。 由于血脑屏障的存在，理化因素和微生物等，其影响在短时间内不易扩散到脑组织。

2023年12月8日 · Here, we report nanozyme-integrated metal-organic frameworks with excellent antioxidant activity and chiral-dependent BBB transendocytosis as anti-neuroinflammatory agents for the treatment of PD.

2016年8月4日 · Using TEM, we were able to visualize the abnormal remodeling to the BBB and the neurovascular unit in the midbrain of STZ-induced diabetic mice and to demonstrate that treatment with topiramate prevented these changes. Male CD-1 mice were administered a single dose of STZ to render them diabetic.

2024年6月1日 · In this study, we constructed a BBB-bindable microbomb with the aim of opening the tank armor-like BBB and enhancing glioma therapy. Besides, a glioma-targeting molecular probe synthesized for identifying the tumor boundary was encapsulated into the microbomb.

结合抗体发现技术和药代动力学分析，确定了优化跨 bbb 运输的结合剂，称为转胞吞作用启用模块 (tem)。随后通过成像评估 tem 的功能活性，以了解骨髓细胞吞噬靶蛋白和细胞的能力。 发现. 我们展示了使用最佳转铁蛋白受体或 cd98 tem 显着增强治疗性抗体的脑暴露。

2020年1月10日 · Our microengineered human BBB model reconstitutes the BBB structure with the brain vascular endothelium and human brain vascular pericytes (HBVPs) in direct contact with 3D network of human ...