源自狂犬病病毒糖蛋白(rabies virus glycoprotein, RVG)的多肽具有高度嗜神经性, 能够特异性结合CNS 中的烟碱型乙酰胆碱受体(nicotinic acetylcholine recep-tor, nAChR), 可通过受体介导的转 …
Efficient neuronal targeting and transfection using RVG and …
2020年5月1日 · The feasibility of Liposome-RVG-Tf to cross BBB and transfect brain cells was demonstrated using an in vitro triple co-culture BBB model. Liposome-RVG-Tf encapsulating …
Development of Novel Therapeutics Targeting the Blood–Brain …
Exosomes that express a fusion protein of rabies virus glycoprotein (RVG) peptide, a short (29 amino acid) peptide derived from the RVG, could cross the BBB and specifically target brain …
基于RVG肽的中枢神经系统靶向递送策略进展 - 搜狐
2023年6月27日 · 源自狂犬病病毒糖蛋白 (rabies virus glycoprotein, RVG)的多肽具有高度嗜神经性, 能够特异性结合CNS中的烟碱型乙酰胆碱受体 (nicotinic acetylcholine receptor, nAChR), 可通 …
Cell-Penetrating and Targeted Peptides Delivery Systems as …
Amid the naturally occurring CPPs, virus-derived peptides have revolutionised targeted drug delivery across the BBB. A rabies virus glycoprotein (RVG-29) readily docks to the nicotinic …
Targeted transport of nanocarriers into brain for theranosis with ...
2018年6月1日 · Currently, peptide derivatives of rabies virus glycoprotein (RVG) have been exploited as delivery ligands to transport nanocarriers across BBB and specifically into the …
Application progress of RVG peptides to facilitate the delivery of ...
RVG-mediated drug delivery systems have been widely applied to treat CNS diseases with great advantages in delivering nanocarriers across the BBB into the brain with biological properties: …
狂犬病毒糖蛋白中多肽片段作为脑靶向药物载体的研究进展 - 知乎
2023年11月4日 · 结果表明，rvg29-cys和壳聚糖结合的纳米载体能够有效地传送β-半乳糖苷酶穿过bbb，并在脑部保持生物活性。rvg肽和壳聚糖的协同效应明显增强了β-半乳糖苷酶在脑部的相 …
联合仿生 MOF-RVG15 纳米制剂比 BBB 更有效地抗小鼠模型中的 …
高 BBB 渗透性使 RVG 15在脑靶向药物输送系统方面具有巨大潜力。 此外，具有高载药能力、可调节功能和受控药物释放的多功能集成纳米平台对于肿瘤治疗至关重要。 沸石咪唑酯骨 …
Efficient neuronal targeting and transfection using RVG and
2020年5月1日 · Liposome-RVG-Tf efficiently translocated across in vitro BBB model and, consecutively, transfected primary neuronal cells. Notably, brain-targeted liposomes promoted …