2015年11月13日 · The best-characterized is the blood-brain barrier (BBB), which separates circulating blood from the brain's extracellular fluid. The barrier is formed by vascular endothelial cells, but astroglial cells and pericytes in the brain are in contact with these cells and play an important role in regulating the passage of molecules across the BBB ( 5 ).

2021年9月1日 · The gut vascular barrier (GVB) represents the inner layer of defense in the multilayered intestinal barrier system that finely regulates the translocation of substances from the intestinal lumen to the systemic circulation.

Context: Berberine (BBR) can regulate enteric glial cells (EGCs) and the gut vascular barrier (GVB). Objective: To explore whether BBR regulates GVB permeability via the S100B pathway. Materials and methods: GVB hyperpermeability in C57BL/6J mice ...

2022年10月2日 · 鉴于肠道神经元是外源性神经纤维的目标，它们的功能紊乱可以改变肠-脑互通和cns驱动的肠道控制。 在稳态条件下，cns因血脑屏障（bbb）与外周隔离，bbb与gvb具有分子和细胞相似性，其局部免疫功能主要由胶质细胞支撑（表1）。

2023年10月9日 · RBC-EV含有聚集的α-syn，可以跨 血脑屏障 (BBB)运输，通过神经胶质功能障碍导致PD的大脑病理学。 该研究使用PD模型小鼠验证了RBC-EV中的α-syn在肠胃道中的传输路径，包括对RBC-EV的放射性标记以及 α-突触核蛋白 转移的直接分析。

2015年11月13日 · We identify a gut-vascular barrier (GVB) in mice and humans that controls the translocation of antigens into the blood stream and prohibits entry of the microbiota. Salmonella typhimurium can penetrate the GVB in a manner dependent on its pathogenicity island (Spi) 2–encoded type III secretion system and on decreased β-catenin–dependent ...

2023年8月1日 · The gut vascular barrier (GVB) is the deepest layer of the gut barrier. It mainly comprised gut vascular endothelial cells, enteric glial cells, and pericytes. The GVB facilitates nutrient absorption and blocks bacterial translocation through its size-restricted permeability.

In this review, we unveil the structural and functional analogies between the GVB and PVB, comparing their peculiar features and highlighting the functional role of pitcher and catcher of the gut-brain axis, including their role in the establishment of immune homeostasis and response upon systemic stimuli.

2021年9月1日 · A breach in the outer mucus and epithelium can be transmitted to the inner gut vascular barrier (GVB), leading to systemic dissemination of microbes or microbe-derived molecules. Several extraintestinal pathologies have been linked to gut microbiota dysbiosis that causes GVB leakage in their early phases.

The identification of a gut–vascular barrier (GVB), consisting of a structured endothelium below the epithelial layer, has led to new evidence on the etiology and management of diseases of the gut–liver axis and the gut–brain axis, with recent implications in oncology as well.