PD-L1 also known as B7-H1 was characterized at the Mayo Clinic in 1999 as an immune regulatory molecule. [8] At that time, it was concluded that B7-H1 helps tumor cells evade anti-tumor immunity. [9]

细胞程序性死亡-配体1（Programmed cell death ligand 1，PD-L1）也称为表面抗原分化簇274（cluster of differentiation 274，CD274）或 B7同源体（B7 homolog 1，B7-H1），是人类体内的一种蛋白质，由CD274基因编码。

PD-L1首次被发现是由华裔学者 陈列平 教授在1999年作为B7家族的第3个成员B7-H1。次年，Tasuku Honjo与哈佛医学院的Gordon Freeman证实B7-H1能够与PD-1结合，抑制T细胞增殖以及细胞因子分泌，负调控淋巴细胞的激活。

在细胞免疫反应中，T细胞的增殖和活化不仅需要 T细胞受体 TCR识别APC或肿瘤细胞表面MHC提呈的第一信号，还需要共刺激分子提供的第二信号，B7家族是目前发现的共刺激分子家族之一,通过CD28受体家族与B7配体家族相互作用，激活或抑制T细胞的活化与增殖。 B7家族，属于免疫球蛋白超家族。 目前已发现11种B7蛋白，即B7-1、B7-2、B7-H1、B7-DC、B7-H2、B7-H3、B7-H4、B7-H5、BTNL2、B7-H6和B7-H7。 B7家族与肿瘤进展关联密切，在肿瘤免疫、自身免 …

Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). Ligation of B7-H1 co-stimulated T-cell...

pdl1（cd274，b7 - h1）是免疫调节领域备受瞩目的关键分子。 它主要表达于多种细胞表面，如肿瘤细胞、抗原提呈细胞等。 通过与程序性死亡受体 1（PD - 1）等相互作用，PDL1 能够传递抑制性信号，在肿瘤微环境中，可抑制 T 细胞的活化与增殖，帮助肿瘤细胞实现 ...

2002年6月24日 · B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on...

2018年10月22日 · b7-h1/pd-1通路代表了典型的肿瘤适应性免疫逃逸机制。当识别肿瘤抗原性时，肿瘤特异性效应t细胞上调pd-1的表达并释放ifn-γ，从而诱导肿瘤和 tme中髓细胞的b7-h1。b7-h1通过与pd-1结合抑制t细胞，阻断打击肿瘤的t细胞攻击。

The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated immune response. Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T-lymph …

2017年1月25日 · In 2002, Lieping Chen discovered the critical role of B7-H1 (PD-L1) as a potential immune evasion mechanism in the tumor microenvironment. B7-H1 is found to be overexpressed in many human tumor tissues, but minimally detected in the normal tissues, which was mainly regulated by IFN-γ .