2017年7月7日 · B7-H3-deficient mice or mice treated with an antagonistic antibody to B7-H3 showed reduced growth of multiple tumors, which depended on NK and CD8 + T cells. With a …

We have demonstrated that: (a) mice lacking either B7-1 or B7-2 develop EAE comparably to wild-type mice; (b) mice lacking both B7-1 and B7-2 or CD28 are highly resistant to EAE …

We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or …

2019年5月21日 · In this study, we show that mouse B7-H3 on DCs has a negative regulatory function for CD4+ T cell-dependent production of anti-dsDNA Abs and contributes to disease …

2003年8月17日 · In this study, however, we show that mouse B7-H3 has a negative regulatory function in T cell–mediated immune responses both in vitro and in vivo. B7-H3 inhibited T cell …

2021年7月1日 · Human B7-H3 mRNA was detectable in spleen and bone marrow of only B-hB7-H3 mice, and B7-H3 antibodies bound well to hB7-H3+ MC38 cells. Furthermore, using the …

1999年9月6日 · Clinical and histologic EAE were markedly reduced in B7-1/B7-2 (-/-) compared with wild-type recipient mice. These results demonstrate that B7 costimulation has critical roles …

2009年2月2日 · B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T-cell responses. To explore physiologic roles of B7-H4, we created B7-H4–deficient (KO) …

Strain specific B7-H3 expression analysis in homozygous B-hB7-H3 mice by western blot. Tissues were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hB7-H3 mice (H/H), and …

2014年12月1日 · B7-H1 knockout mice represent an important model to elucidate further molecular and cellular mechanisms involved, among others, in autoimmunity development and …