2021年6月11日 · A hallmark of systemic lupus erythematosus (SLE) is aberrant B-cell differentiation and function, and the pathogenic roles of B cells are multifaceted.

B cells exert a prominent contribution to the pathogenesis of systemic lupus erythematosus (SLE). Here, we review the immune mechanisms underlying autoreactive B cell activation in SLE, …

Abnormalities in B cells play pivotal roles in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance mechanisms …

2022年3月1日 · Recent findings: SLE carries characteristic B cell abnormalities, which offer new insights into B cell differentiation and their disturbances including discoveries of pathogenic B …

Global and sustained B-cell depletion is predicated on the flawed premise that B cells have only pathogenic roles in SLE; yet, experimental evidence for protective roles for B cells in...

B cell hyperactivity is a hallmark of the complex autoimmune disease systemic lupus erythematosus (SLE), which has justified drug development focusing on B cell altering agents …

2024年11月7日 · Emerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesponsive to signalling through the B cell receptor …

Emerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesponsive to signalling through the B cell receptor (BCR) …

2025年2月18日 · Dual receptor B cells exhibit autoreactivity in SLE and may participate in the production of autoantibodies, exacerbating the disease pathology. The relationship between …

2019年12月26日 · This review will summarize the latest progress in basic research on B cells to better understand the pathogenesis of SLE and will discuss the outcomes of B-cell-targeting …