B Cell Development: Maturation, Activation, and Differentiation
B-cell development from HSC (hematopoietic stem cell) to mature B cell takes 1 to 2 weeks. The development of B-cells starts in the bone marrow with the asymmetric division of an HSC. It continues through progressively more differentiated progenitor stages to produce common lymphoid progenitors (CLPs), which can give rise to B or T cells.
2014年11月13日 · Overview of B cell development • B cells are generated in the bone marrow • Takes 1-2 weeks to develop from hematopoietic stem cells to mature B cells • Sequence of expression of cell surface receptor and adhesion molecules which allows for differentiation of B cells, proliferation at various stages, and movement
B lymphocytes: how they develop and function | Blood
2008年9月1日 · A histopathological montage of normal and malignant human B-lineage cells. (A) Bone marrow aspirate of ALL cells exhibiting a high nuclear to cytoplasmic ratio, finely dispersed chromatin, indistinct nucleoli, and blue-gray cytoplasm. (B) Bone marrow biopsy showing effacement of the marrow architecture by a monotonous population of ALL ...
Microenvironmental niches in the bone marrow required for B-cell ...
2006年2月1日 · All known requisite factors for B-cell development are thought to be produced by the cells that are located in the bone marrow. Primary osteoblasts produce factors that support early...
B Cell Development in the Bone Marrow Is Regulated by …
2016年3月21日 · B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).
The Bone Marrow Microenvironment in B-Cell Development and …
This review summarizes the role of the bone marrow microenvironment in regulating healthy B-cell development and B-cell acute lymphoblastic leukemia (B-ALL). Understanding of how the microenvironment contributes to B-ALL pathogenesis and treatment failure will allow us to devise microenvironment-targeted therapies for B-ALL in the future.
The Development of B Cells in the Bone Marrow Is Controlled …
2000年1月1日 · Stromal cells produce and release IL-7. Therefore, they play an important role in the regulation of B cell development in the bone marrow, mainly controlling the size of the B cell compartment (from commitment to the pre-B cell stage). In the bone marrow, different types of hematopoietic cells develop.
B Cell Development, Activation and Effector Functions
2014年1月1日 · B cells mature from bone marrow HSCs through several developmental stages that are independent of antigen. During this process, negative selection removes potentially autoreactive B cells, establishing central B cell tolerance.
Three-dimensional chromatin reorganization regulates B cell development ...
2024年6月12日 · Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (pro-) B cells. These changes result in increased interactions at the...
B Cell Development Pathways - Annual Reviews
Here we review progress in understanding some aspects of this process in the mouse bone marrow, focusing on delineation of the earliest stages of commitment, on pre-B cell receptor selection, and B cell tolerance during the immature-to-mature B cell transition.