CD22-B细胞受体辅因子 - 知乎 - 知乎专栏
CD22主要表达于成熟B细胞，是具有调控B细胞激活作用的细胞表面粘附分子，有助于B细胞对抗原反应敏感性的控制 [1] [2] [3]。 Tedder TF团队进一步证明了CD22表达在B细胞中具有特异性，并且在小鼠和人类中都受到发育调控 [4]。 如Figure 1所示，CD22可在原B细胞和前B细胞中表达，并逐渐转移到细胞表面，但是表达水平低；在IgM+和IgD+的成熟B细胞高表达，在滤泡性B细胞、套细胞、边缘区B细胞也高表达，但最终在CD27+记忆B细胞，尤其是浆细胞中，表达下调 [5]。 …
CD22: A Regulator of Innate and Adaptive B Cell Responses and ...
2018年9月28日 · CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named "CD22" in 1984 at the 2nd International workshop in Boston (1). Several excellent reviews have detailed CD22 functions, CD22-regulated signaling pathways and B cell subsets r …
Frontiers | CD22: A Regulator of Innate and Adaptive B Cell …
2018年9月27日 · We found that engagement of CD22 on human B cells by anti-CD22 Ab inhibits the expression of PRDM1 in response to TLR7 ligand or a combination of anti-IgM plus TLR7 ligand stimulation . PRDM1 encodes Blimp1, a key transcription factor required for B cells to mature into antibody-secreting plasma cells.
Molecular basis of human CD22 function and therapeutic targeting - Nature
2017年10月2日 · CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that...
Surface CD22 is a highly sensitive and specific B lineage marker …
2022年4月23日 · Our data show that sCD22 can be used as a reliable and preferred marker for the diagnosis of B-ALL in place of cCD22 and cCD79a in view of its associated technological advantages. These findings also provide the basis for an increasing use of anti-CD22 antibody and/or CD22 CAR T cell therapy in B-ALL.
CD22: A Multifunctional Receptor That Regulates B
2005年1月1日 · CD22 is expressed on the surface of mature B cells (B) within lymphoid follicle marginal zones, mantle zones, and germinal centers, but not by T cells (T), monocytes (M), neutrophils (N), red blood cells (RBC), platelets (P), or dendritic cells (DC).
Expression and Function of CD22, a B-cell Restricted Molecule
2002年4月25日 · In this paper, we show that: (i) CD22 is expressed on the surface of B lymphocytes during the transition of pro-B cells to pre-B cells; (ii) CD22 expression is upregulated on B cells activated with a variety of stimuli; (iii) CD22 is tyrosine-phosphorylated after BCR engagement but not after cross-linking of CD38 or CD40; and (iv) CD22 is not ...
Human CD22 Inhibits Murine B-cell Receptor Activation in a Human CD22 …
2017年11月1日 · Here, we report development of a transgenic mouse expressing human CD22 (hCD22) in B-cells and assess its ability to functionally substitute for murine CD22 (mCD22) for regulation of BCR signaling, antibody responses, homing, and tolerance.
Analysis of murine CD22 during B cell development: CD22 is
CD22 is a B cell-restricted glycoprotein involved in cell adhesion and signaling. Since CD22 is likely to play an important role in interactions between B cells and other cells, and in regulating signaling thresholds, we characterized the expression of murine CD22 …
CD22 regulates thymus-independent responses and the lifespan of B cells ...
1996年12月26日 · Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR)...