Beta-hydroxybutyrate (BHB) is a chemical that is made by the body. It provides energy when not enough carbohydrates or sugars have been eaten. BHB can also be made in the...

2024年11月27日 · 哺乳动物进化出复杂的营养响应途径，将外部能量来源与内部代谢稳态相联系，其中 β-羟基丁酸（BHB）是一种关键代谢物，其水平在碳水化合物供应不足时升高，如饥饿、间接性禁食、生酮饮食或运动之后。 这引发了人们对研究BHB在肥胖中的潜在应用的兴趣。 近期，贝勒医学院徐勇教授团队与斯坦福大学 Jonathan Z. Long 教授团队合作，在 Cell 期刊发表了题为：A β-hydroxybutyrate shunt pathway generates anti-obesogenic ketone metabolites 的研 …

Teach and practice the letter /b/ sound while singing and listening to this fun and entertaining song packed with colorfully animated vocabulary...

2025年1月9日 · β-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. Here, we identify a previously undescribed BHB secondary metabolic pathway via CNDP2-dependent enzymatic conjugation of BHB and free amino acids.

Here, we review the signaling activities of the endogenous metabolite β-hydroxybutyrate (BHB). BHB is the most abundant ketone body in mammals. Ketone bodies are small molecules synthesized primarily in the liver from fats that circulate through the bloodstream during fasting, prolonged exercise, and when carbohydrates are restricted.

2024年7月29日 · In metabolic states where glucose is limited, ketone bodies, predominantly β-hydroxybutyrate (BHB), act as alternative fuel sources. Elevated levels of BHB have been found in the ischemic hemispheres of animal models of stroke, supporting its role in the pathophysiology of cerebral ischemia.

2024年7月17日 · Endogenous or exogenous BHB elevation is a candidate intervention for many indications that leverage its fuel and signal functions. Exogenous ketones partially isolate the effects of BHB from those of diet. Leading areas of investigation include neurodegeneration and …

最终，他们将这种肠道细胞生长放缓追溯到BHB---BHB通常由肝脏产生，作为“饥饿反应”的一部分，在这项研究中，它由低碳水化合物的生酮饮食引发。 β-羟基丁酸对肠上皮细胞生长的抑制作用。图片来自Nature, 2022, doi:10.1038/s41586-022-04649-6。 众所周知，BHB在低碳水化合物条件下作为关键器官的替代燃料来源发挥作用。 然而，这些作者发现它不仅是一种燃料来源，也是一种有效的减缓肠道细胞生长的信号，至少对肠壁细胞是如此。 他们只需在小鼠的水中或者通过 …

2016年12月5日 · Watch the Best Nursery Rhymes Collection for Children By All Babies Channel, Click Here: \r<br>\r<br>Sing along to the ABC Phonics Song by All Babies Channel and learn your Alphabets in a fun way.

2023年10月23日 · BHB is the main ketone body produced by the liver in a ketogenic state when carbohydrate sources are restricted or stores are exhausted. BHB enters mitochondria of cells where it is metabolized to products that enter the Krebs cycle and produce ATP, the simplest energy currency for local cellular processes.