Histamine H3-receptor Blockers H3-receptors are located within the brain and have been found to be associated with wakefulness. Thiaperamide was the first H3-blocker created but was shortly found to be toxic to the liver and became replaced by pitolisant.

Nizatidine is a histamine H 2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. [2] It was patented in 1980 and approved for medical use in 1988. [3][4] It was developed by Eli Lilly.

Axid is a competitive, reversible inhibitor of histamine at the his-tamine H2-receptors, particularly those in the gastric parietal cells. Antisecretory Activity—1. Effects on Acid Secretion:...

尼扎替丁为强效H2受体拮抗药，作用于胃酸分泌细胞，阻断胃酸形成并能使基础胃酸降低，亦可抑制食品和化学刺激所致的胃酸分泌，如胃泌素和乙酰胆碱。 作用强度类似雷尼替丁，优于西咪替丁。 临床研究表明，本品能显著的抑制夜间胃酸分泌达10h。 本药在正常状态下，不影响胃液中的胃蛋白酶活性，但可影响分泌量。 无抗男性激素作用。 对心血管神经及内分泌糸统无不良反应，也不影响肝脏细胞色素P450氧化酶活性。 口服吸收好，生物利用度大于90%。 PBP为30%，另 …

2024年7月2日 · What is Axid AR? Axid AR is non-prescription medicine that contains nizatidine. Nizatidine is a histamine-2 blocker that works by decreasing the amount of acid produced by the stomach. Axid AR works by reducing the production of stomach acid that can cause heartburn. Axid AR may also be used for purposes not listed in this medication guide ...

2022年9月15日 · Axid (nizatidine) is indicated for maintenance therapy for duodenal ulcer patients, at a reduced dosage of 150 mg h.s. after healing of an active duodenal ulcer. The consequences of continuous therapy with Axid (nizatidine) for longer than 1 year are not known.

2021年3月3日 · H3 and H4 targeting antihistamine compounds are available mostly as laboratory supplies and not currently available to consumers as prescriptions or as OTC medications. Initial research has shown that H3 and H4 receptors may play a pivotal role in cases where common allergic responses are noted ( 6 ).

2024年8月26日 · Antihistaminic: For allergic conjunctivitis due to foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema; adjunctive to epinephrine and other standard measures in treatment of anaphylactic reactions - after the acute manifestations have been controlled.

Axid: Nizatidine belongs to the family of medications called H2-receptor antagonists. Nizatidine works by reducing the amount of acid secreted by the stomach. Reducing the acid helps to reduce the pain of stomach and intestinal ulcers and heartburn and to assist in the healing of ulcers and damage caused by gastroesophageal reflux disease.

Action And Clinical Pharmacology: Nizatidine is a competitive, reversible inhibitor of the histamine H2 receptor of gastric-acid secreting cells. Nizatidine is not an anticholinergic agent. It inhibits nocturnal gastric-acid secretion and gastric-acid secretion stimulated by food, caffeine, betazole and pentagastrin.