2025年3月30日 · ATP6AP2 (ATPase H+ Transporting Accessory Protein 2) is a Protein Coding gene. Diseases associated with ATP6AP2 include Parkinsonism With Spasticity, X-Linked and Congenital Disorder Of Glycosylation, Type Iir. Among its related pathways are Innate Immune System and ACE Inhibitor Pathway, Pharmacodynamics.

2024年5月29日 · ATP6AP2, an accessory subunit of V-ATPase, plays important roles in multiple cell types/organs and multiple signaling pathways. However, little is known whether and how ATP6AP2 in OBs regulates...

该基因编码一种与三磷酸腺苷酶 (ATPases) 相关的蛋白质。 质子转运 ATP 酶在能量守恒、二次主动转运、细胞内区室酸化和细胞 pH 稳态中具有重要作用。 存在三类 ATP 酶 - F、P 和 V。 液泡 (V 型) ATP 酶具有跨膜质子传导部分和膜外催化部分。 已发现编码的蛋白质与 V 型 ATP 酶的跨膜区有关。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein that is associated with adenosine triphosphatases (ATPases).

2022年4月4日 · Adenovirus-mediated knockdown of ATP6AP2 (shR-ATP6AP2) accelerated the progress of heart failure. After TAC was induced, shR-ATP6AP2 significantly deteriorated heart function and fibrosis...

2021年7月6日 · To study ATP6ap2 function in the proximal tubule, we used an inducible shRNA Atp6ap2 knockdown rat model (Kd) and an inducible kidney-specific Atp6ap2 knockout mouse model. Both animal lines showed higher proteinuria with elevated albumin, vitamin D binding protein, and procathepsin B in urine.

2025年2月9日 · Results suggest that full-length ATP6AP2 contributes to the assembly of the V-ATPase proton pore and that impairment of this function affects ER homeostasis and PCP signaling. Data show that TMEM9 binds to and facilitates assembly of vacuolar-ATPase (v-ATPase), a vacuolar proton pump, resulting in enhanced vesicular acidification and trafficking

2021年8月1日 · The ATP6ap2 (Pro)renin receptor protein associates with H + -ATPases which regulate organellar, cellular, and systemic acid-base homeostasis. In the kidney, ATP6ap2 colocalizes with H + -ATPases in various cell types including the cells of the proximal tubule.

ATP6AP2, an accessory subunit of V-ATPase, plays important roles in multiple cell types/organs and multiple signaling pathways. However, little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone formation.

2024年5月29日 · ATP6AP2, an accessory subunit of V-ATPase, plays important roles in multiple cell types/organs and multiple signaling pathways. However, little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone formation.

2020年4月17日 · The ATP6AP2 gene encodes a transmembrane protein that is an essential accessory component of the vacuolar ATPase required for lysosomal degradative functions and autophagy.