Arsenic trioxide induces macrophage autophagy and ... - Nature
Jan 18, 2021 · ATO increased the fluorescence intensity of LC3 and LAMP1, while decreased that of p62 in the aortic sinus, compared to controls (Fig. 7B–E). Furthermore, ATO enhanced LC3 …
Maximizing arsenic trioxide's anticancer potential: Targeted ...
Sep 1, 2024 · In a recent study, co-treatment of cervical cancer cells with cyclosporin A and ATO resulted in a significant increase of LC3-II expression compared to single drug treatment. In …
Nanodiamond autophagy inhibitor allosterically improves the arsenical ...
Oct 19, 2018 · Arsenic trioxide (ATO) is a successful chemotherapeutic drug for blood cancers via selective induction of apoptosis; however its efficacy in solid tumors is limited. Here...
Chinese Medical Journal
Jan 17, 2025 · Mechanistically, in vitro studies have shown that nontoxic concentrations of ATO can activate both ERK and phosphoinositide 3-kinase-serine/threonine kinase (PI3K-AKT) …
LC3蛋白：细胞自噬中的关键执行者 - 知乎 - 知乎专栏
LC3蛋白（也称为 Microtubule-associated protein 1 light chain 3）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。 通过检测LC3蛋白的表达水平和形态变化，可以研究 …
[Effect of Cell Autophagy on the Apoptosis of Hepatocellular …
The autophagy related proteins (LC3 and Beclin1) were detected by immunofluorescence. The cell apoptosis was measured by flow cytometry. Results: With 5-20 μmol/L of ATO, HepG2 …
Arsenic Inhibits Proliferation and Induces Autophagy of Tumor …
Jun 15, 2023 · ATO diminished the number of tumor cells from patients with WT and mutant EGFR, down-regulated the expression or phosphorylation of EGFR, pmTOR, PI3K, PTEN, …
Arsenic trioxide induces autophagic cell death in osteosarcoma …
Jan 29, 2018 · In the present study, we showed that ATO increased autophagic flux in the human osteosarcoma cell line MG-63, as evidenced by the upregulation of LC3-II and downregulation …
细胞自噬在三氧化二砷诱导肝癌细胞凋亡中的作用研究
Results With 5- 20 μmol/L of ATO, HepG2 cells exposed to 3-MA had significantly lower viability (P <0.05) and higher early apoptosis (P <0.05) than those without exposure to 3-MA. …
自噬标志物—LC3检测要点 - 知乎 - 知乎专栏
LC3/Atg8 被具有蛋白内切酶活性的 Atg4 在羧基端剪切，生成胞浆型 LC3-I。 在自噬形成时，胞浆型LC3-I通过 Atg7 和 Atg3 （分别对应泛素激活酶E1和泛素结合酶E2）参与的类泛素样反应， …