5 天之前 · Monoclonal Antibody for studying ATG7. Validated for IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Atg7 (D12B11) Rabbit Monoclonal Antibody (CST #8558) is ready to ship.

Atg 基因通过 Atg12-Atg5 以及 LC3-II (Atg8-II) 复合体，控制自噬体的形成。 Atg12 通过一个需要 Atg7 和 Atg10（分别对应 E1 和 E2 样酶）参与的泛素样反应，结合到 Atg5。 Atg12-Atg5 接合后，与 Atg16 通过非共价相互作用形成一个大复合体。 LC3/Atg8 被 Atg4 蛋白酶在羧基端剪切后产生胞质 LC3-I。 LC3-I 也是通过一个需要 Atg7 和 Atg3（分别对应 E1 和 E2 样酶）参与的泛素样反应，结合到磷脂酰乙醇胺 (PE)。 脂质化形式的 LC3，也称作 LC3-II，附着到自噬体的膜上。 …

2025年4月1日 · SignalSilence ® Atg7 siRNA I from Cell Signaling Technology (CST) allows the researcher to specifically inhibit Atg7 expression using RNA interference, a method whereby gene expression can be selectively silenced through the delivery …

Atg12 以需要 Atg7 和 Atg10（分别为 E1 和 E2 样酶） 的泛素样反应与 Atg5 偶联。 然后，Atg12–Atg5 连接物与 Atg16 非共价反应形成更大的复合物。 LC3/Atg8 的 C 端被 Atg4 蛋白酶酶切后生成细胞质 LC3-I。

Atg7 (D12B11) Rabbit mAb recognizes endogenous levels of total Atg7 protein. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Atg7 protein. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents (1,2).

4 天之前 · Atg7 Antibody detects endogenous levels of total Atg7 protein. The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

Atg7 Antibody detects endogenous levels of total Atg7 protein. The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles (4-6). This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10 (7,8).

Signaling Technology (CST) allows the researcher to specifically inhibit Atg7 expression using RNA interfer-ence, a method whereby gene expression can be selectively silenced through the delivery of double stranded RNA mol-ecules into the cell. All SignalSilence® siRNA products from CST are rigorously tested in-house and have been shown to

Antibody: Atg7 . Catalog number: 8558. Summary: Rabbit monoclonal IgG against a synthetic peptide corresponding to residues near the amino terminus of human Atg7 protein. Reacts with human, mouse, and rat. It is predicted to react based on 100% sequence homology with monkey, and bovine. Suitable for western blot and immunoprecipitation.