在此过程中，首先Atg7作为类E1泛素活化酶激活Atg12；然后Atg12被传递给类E2泛素转移酶Atg10；最后Atg12与Atg5结合形成复合物。

It goes through destroying and recycling the cytoplasmic organelles and macromolecules. During the initiation of autophagy, ATG7 acts like an E-1 enzyme for ubiquitin-like proteins (UBL) such …

2025年3月28日 · ATG7 (Autophagy Related 7) is a Protein Coding gene. Diseases associated with ATG7 include Spinocerebellar Ataxia, Autosomal Recessive 31 and Fatty Liver Disease 1. …

自噬（autophagy=self-eating）意为自体吞噬，是真核细胞在自噬相关基因（autophagy related gene，Atg）的调控下利用溶酶体降解自身细胞质蛋白和受损细胞器的过程。 自噬可防止细胞 …

2024年3月29日 · The E1-like ubiquitin-activating enzyme autophagy-related gene 7 (ATG7) is a critical factor that initiates classic autophagy reactions by promoting the formation and...

Here, we systematically review the biological functions of ATG7, discussing the impact of its impairment on signalling pathways and human pathology. Future studies illuminating the …

2023年12月11日 · We report that autophagy-related gene 7 (ATG7) modulates p53 activity to regulate cell cycle and survival during metabolic stress, and that indicates Atg7 is functionally …

该基因编码一种 E1 样激活酶，该酶对于自噬和细胞质至液泡的运输至关重要。 编码的蛋白质也被认为在长期代谢应激期间调节 p53 依赖性细胞周期途径。 它与多种功能相关，包括轴突膜运 …

2020年8月13日 · Endothelial cell (EC) inflammation and permeability are critical pathogenic mechanisms in many inflammatory conditions including acute lung injury. In this study, we …

2025年2月13日 · Here, we found that microglia-specific deletion of Atg7 in an AD mouse model impaired microglia coverage of Aβ plaques, increasing plaque diffusion and neurotoxicity. …