【热点】研究自噬不得不说的关键分子 - 知乎
Atg5是参与自噬泡中吞噬细胞膜延伸的关键蛋白，它与Atg12形成组成型的复合物。 在此过程中，首先Atg7作为类E1泛素活化酶激活Atg12；然后Atg12被传递给类E2泛素转移酶Atg10；最 …
Autophagy protein 5 - Wikipedia
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the …
自噬信号通路 | Cell Signaling Technology
Atg 基因通过 Atg12-Atg5 以及 LC3-II (Atg8-II) 复合体，控制自噬体的形成。 Atg12 通过一个需要 Atg7 和 Atg10（分别对应 E1 和 E2 样酶）参与的泛素样反应，结合到 Atg5。
自噬相关蛋白ATG5调控细胞自噬和凋亡的研究进展 - 中华医学杂志
我们在昆虫细胞中的研究发现，全长的ATG5 (相对分子质量31 000)能调控细胞自噬进程，而截短分子ATG5－tN (相对分子质量24 000)则具有触发细胞凋亡的作用，这些结果为ATG5在昆虫 …
ATG5 Gene - GeneCards | ATG5 Protein | ATG5 Antibody
Mar 28, 2025 · ATG5 (Autophagy Related 5) is a Protein Coding gene. Diseases associated with ATG5 include Spinocerebellar Ataxia, Autosomal Recessive 25 and Stomatitis. Among its …
Autophagy regulator ATG5 preserves cerebellar function by
Jan 15, 2025 · Here, we find that the core autophagy protein ATG5 regulates PC survival beyond its conventional role in clearing protein aggregates and mitochondria. Instead, ATG5 acts …
自噬相关 5（ATG5）基因 | MCE
该基因编码的蛋白质与自噬蛋白 12 结合，在泛素样结合系统中起 E1 样激活酶的作用。 编码的蛋白质参与多种细胞过程，包括自噬囊泡形成、氧化损伤后线粒体质量控制、先天抗病毒免疫反 …
ATG5: A central autophagy regulator implicated in various human ...
Sep 5, 2022 · ATG5, a key component of autophagy, regulates the formation of the autophagosome, a hallmark of autophagy. ATG5 binds with ATG12 and ATG16L1 resulting in …
Atg5: more than an autophagy factor - Nature Cell Biology
Oct 1, 2006 · Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now …
9474 - Gene ResultATG5 autophagy related 5 [ (human)]
ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells. Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 …