In molecular biology, autophagy related 3 (Atg3) is the E2 enzyme for the LC3 lipidation process. [1] It is essential for autophagy. The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the LC3 lipidation reaction.

2021年6月21日 · Here, we summarize the current knowledge of ATG3 in autophagosome formation, highlight its binding partners and binding sites, review its autophagy-dependent functions, and provide a brief introduction into its autophagy-independent functions.

2025年3月28日 · ATG3 (Autophagy Related 3) is a Protein Coding gene. Diseases associated with ATG3 include Neurodegeneration With Brain Iron Accumulation and Granulomatous Amebic Encephalitis. Among its related pathways are Autophagy and Selective autophagy.

ATG3 is one of the key genes involved in autophagy, and its homologs are common in eukaryotes. During autophagy, ATG3 acts as an E2 ubiquitin-like conjugating enzyme in the ATG8 conjugation system, contributing to phagophore elongation.

2014年6月1日 · Atg3 is the ubiquitin-carrier-like (E2-like) protein that mediates conjugation of Atg8 to phosphatidylethanolamine (PE), an essential step for autophagy. 24 S. cerevisiae Atg3 was crystallized in several studies.

2018年1月8日 · Here we report a thiol-dependent process that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7. When...

2021年6月20日 · Autophagy-related (ATG) genes are indispensable for autophagosome formation. ATG3 is one of the key genes involved in autophagy, and its homologs are common in eukaryotes. During autophagy, ATG3 acts as an E2 ubiquitin-like conjugating enzyme in the ATG8 conjugation system, contributing to phagophore elongation.

2020年5月26日 · Recently, there is accumulating evidence showing that some ATG proteins have the ability to directly interact with membranes, transfer lipids between membranes and regulate lipid metabolism. A...

Dysfunctional autophagy by Atg3 deletion inhibited mitochondrial removal during pluripotency induction, resulting in decreased reprogramming efficiency and accumulation of abnormal mitochondria in established iPSCs.

2025年2月8日 · ATG3 gene and its gene family may play an important role in transformation of myelodysplastic syndrome. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.