ATG14 targets lipid droplets and acts as an autophagic ... - Nature
2024年1月20日 · In this study, we showed that ATG14 targets LDs, interacts with ATG8s via LC3 interaction region (LIR), and acts as an autophagic receptor to regulate LD turnover via …
ATG14 Gene - GeneCards | BAKOR Protein | BAKOR Antibody
2024年12月24日 · ATG14 (Autophagy Related 14) is a Protein Coding gene. Diseases associated with ATG14 include Neurodegeneration With Brain Iron Accumulation and Liver Carcinoma In …
Nat Commun丨揭示ATG14做为自噬受体介导脂滴自噬机制和功能
ATG14 是自噬起始复合物 PI3KC3-C1 的重要成员，与VPS34、 Beclin1 和 p150 形成PI3KC3-C1复合物，介导磷脂酰肌醇3-磷酸（PI3P）的产生，以此来启动自噬前体的形成。 在最终自 …
ATG14 promotes membrane tethering and fusion of …
2015年2月9日 · Here we report that ATG14 (also known as beclin-1-associated autophagy-related key regulator (Barkor) or ATG14L), an essential autophagy-specific regulator of the class III …
Atg14: a key player in orchestrating autophagy - PubMed
Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase is an essential process in autophagy. Atg14, a specific subunit of one of the PtdIns 3-kinase complexes, targets the …
ATG14 plays a critical role in hepatic lipid droplet homeostasis
2023年11月1日 · Autophagy-related 14 (ATG14) is a key regulator of autophagy. ATG14 is also localized to lipid droplet; however, the function of ATG14 on lipid droplet remains unclear. In …
Nat Commun | 华中科技大学丁彬彬教授课题组揭示ATG14做为自 …
2024年1月30日 · ATG14是自噬起始复合物PI3KC3-C1的重要成员，与VPS34、Beclin1和p150形成PI3KC3-C1复合物，介导磷脂酰肌醇3-磷酸（PI3P）的产生，以此来启动自噬前体的形成。 …
MARCH7-mediated ubiquitination decreases the solubility of ATG14 …
2023年9月26日 · Here, we report that MARCH7 (membrane-associated ring-CH-type finger 7), an E3 ubiquitin ligase, inhibits autophagy by ubiquitinating ATG14. MARCH7 significantly …
Plant Cell | 刘芬博士等揭示自噬蛋白ATG14介导PI3K复合体调控植 …
研究发现， atg14a14b 双突变体具有典型的自噬突变体的表型，对营养胁迫敏感并且早衰，突变体中积累了较多的ATG1和ATG8等自噬蛋白，并且自噬小体的数量显著下调。 此外，通过杂交 …
自噬相关 14（ATG14）基因 | MCE - MCE-生物活性分子大师
Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of …
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