Autophagy-related protein 101 also known as ATG101 is a protein that in humans is encoded by the C12orf44 gene (chromosome 12 open reading frame 44). [5] Autophagy is the process of sequestering target proteins, organelles, aggregates, and other cytoplasmic species inside large membrane-bound vesicles and delivering them to lysosomes for ...

2025年3月28日 · ATG101 (Autophagy Related 101) is a Protein Coding gene. Diseases associated with ATG101 include Cholangiocarcinoma and Neurodegeneration With Brain Iron Accumulation. Among its related pathways are Alzheimer's disease and miRNA effects and Selective autophagy.

Here, we identify a novel mammalian Atg13 binding protein, named Atg101. Atg101 shows no homology with other Atg proteins, and is conserved in various eukaryotes, but not in Saccharomyces cerevisiae. Atg101 associates with the ULK-Atg13-FIP200 complex, most likely through direct interaction with Atg13.

2015年6月1日 · The crystal structure of the Atg101–Atg13 complex elucidates the function of Atg101 and sheds light on the molecular mechanisms of autophagy initiation in higher eukaryotes.

2022年10月27日 · We quantified the levels of various cancer hallmarks and identified ATG101 as the major risk factor for overall survival in HCC. A robust ATG101-related gene signature (ATS) for prognosis was...

2019年4月5日 · Atg101 is an autophagy-related gene identified in worms, flies, mice, and mammals, which encodes a protein that functions in autophagosome formation by associating with the ULK1-Atg13-Fip200 complex.

Now, structural and cell biological analysis of Atg101 together with its binding partner Atg13 reveal that Atg101 is required for stabilization of "uncapped" Atg13 in most eukaryotes and also for recruitment of downstream Atg proteins through the newly identified WF motif.

2024年12月10日 · Gene target information for ATG101 - autophagy related 101 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Here, we describe the generation and characterization of an Atg101 loss-of-function mutant in Drosophila and report on the roles of Atg101 in maintaining tissue homeostasis in both adult brains and midguts.

2025年2月8日 · ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma. ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.