2015年8月19日 · Invitrogen Anti-Phospho-Tau (Ser202, Thr205) Monoclonal (AT8), Catalog # MN1020. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse samples.

2024年2月6日 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. AT8, which recognizes paired helical filament (PHF) tau, is …

1995年4月21日 · As such, monoclonal antibody AT8 is widely used. By a combination of site-directed mutagenesis of recombinant tau and in vitro phosphorylation, we show that AT8 requires tau protein to be phosphorylated at both serine 202 and threonine 205 (using the numbering of the longest human brain tau isoform.

5 天之前 · A number of kinases have been shown to phosphorylate tau at Ser202 and Thr205 (aka AT8) including GSK-3β and CDK5. Tau is known to form paired helical filaments when phosphorylated at these residues (4).

Invitrogen Anti-Phospho-Tau (Ser202, Thr205) Monoclonal (AT8), Catalog # MN1020B. Tested in Immunohistochemistry (Paraffin) (IHC (P)) and ELISA (ELISA) applications. This antibody reacts with Human samples. Supplied as 50 µg purified antibody (0.1 mg/mL).

2016年1月21日 · AT8 is a PHF-tau-specific monoclonal antibody that is a commonly used marker of neuropathology because of its recognition of abnormally phosphorylated tau. Previous reports described the AT8 epitope to include pS202/pT205. Our studies support and extend previous findings by also identifying pS208 as part of the binding epitope.

Recognizes phosphorylated paired helical filament tau. Recognises tau protein phosphorylated at both serine 202 and threonine 205. No cross-reactivity with unphoshorylated tau. No Available Comments. To make a comment you must login or register. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, Laferla FM.

2016年2月5日 · AT8是一种PHF-tau特异性单克隆抗体，由于可识别异常磷酸化的tau，因此是神经病理学的常用标记。 先前的报道描述了AT8表位包括pS202 / pT205。 我们的研究还通过鉴定pS208作为结合表位的一部分来支持和扩展先前的发现。

识别的p-tau的磷酸化位点不太一样，at8是ser202，thr205。其他不记得

1995年4月21日 · By a combination of site-directed mutagenesis of recombinant tau and in vitro phosphorylation, we show that AT8 requires tau protein to be phosphorylated at both serine 202 and threonine 205 (using the numbering of the longest human brain tau isoform).