2015年8月19日 · Invitrogen Anti-Phospho-Tau (Ser202, Thr205) Monoclonal (AT8), Catalog # MN1020. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse samples. Supplied as 100 µg purified antibody (0.2 mg/mL).

2024年2月6日 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. AT8, which recognizes paired helical filament (PHF) tau, is …

Invitrogen Anti-Phospho-Tau (Ser202, Thr205) Monoclonal (AT8), Catalog # MN1020B. Tested in Immunohistochemistry (Paraffin) (IHC (P)) and ELISA (ELISA) applications. This antibody reacts with Human samples. Supplied as 50 µg purified antibody (0.1 mg/mL).

2025年3月13日 · C-F Representative images of routine AT8 IHC with and fluorescent neutravidin labeling of proximity biotinylated proteins with AT8 ProPPr in adjacent sections from AD (C), PiD (D), CBD (E), and PSP (F) cases. Staining patterns on adjacent sections are evenly matched between the IHC and proximity-biotinylation of phospho-tau in macroscopic ...

2015年6月9日 · Using monoclonal antibodies recognizing different phosphorylated tau epitopes, AT8 or MC1 (specific for conformational epitopes on PHF tau), we observed tau inside of microglia as intracellular...

2020年1月7日 · Immunohistochemistry (IHC) using monoclonal antibody (Mab) AT8 to hyperphosphorylated tau showed that all the human tau strains induced significant amounts of tau pathologies in the hippocampus...

2023年1月20日 · Rats inoculated with human tau fibrils showed as early as 4 months after inoculation a spread of phosphorylated tau protein at the AT8 epitopes throughout the brain, dramatically faster ...

The resultant detergent-insoluble tau shows deficient phosphorylation on AT8, AT100, AT180 and PHF1 epitopes, indicating inter-domain cooperativity.

At 4 months of age, AT8 immunoreactivity was markedly increased, particularly in layer V of the frontal cortex ( Figure 8 E) and the CA1/2 pyramidal layers ( Figure 8 F), along with the...