2024年12月6日 · This was an ambitious study using single-nucleus RNA-Seq to characterize astrocyte heterogeneity across five brain regions in 32 donors who spanned the spectrum of Alzheimer’s disease neuropathology. The authors’ analysis of normal brains revealed astrocyte heterogeneity across the neocortex.

2023年3月4日 · To better model how GRN loss of function relates to TDP-43 pathology, co-first authors de Majo and Mark Koontz turned to the human induced astrocyte/neuron mini organoid system they had previously developed (Krencik et al., 2017). They knocked out GRN in the neurons, the astrocytes, or both, and then looked for signs of TDP-43 shenanigans four ...

2021年11月9日 · Astrocyte With Appetite. Cultured mouse astrocytes treated with gemfibrozil and retinoic acid (right) ingurgitated more Aβ (white) than did untreated cells (left), and sequestered it into their lysosomes (red). [Courtesy of Raha et al., Science Signaling, 2021.] [Courtesy of Raha et al., Science Signaling, 2021.]

2023年10月4日 · News: Astrocyte Receptor Suppresses Neurotoxic Lipids, Preserves Neurons; It’s exciting to see advancements in research that could lead to innovative clinical interventions. This study provides the first evidence of a regulatory role of TMEM164 in astrocyte activation within the nervous system.

2025年3月7日 · As for astrocytes, three subsets emerged. One expressed high levels of EphA4 along with genes involved in astrocyte reactivity, phagocytosis, and synapse elimination. The latter included the complement protein C3, a downstream effector of the microglial-derived C1q protein, as well as CD44, a surface receptor for C1q.

2024年12月5日 · “The coexistence of multiple astrocyte phenotypes suggests that we should address astrocyte heterogeneity, stratify astrocyte subtypes, and consider multiple astrocyte targets for developing biomarkers. In summary, we should think about astrocytes the way we think about neurons,” he wrote to Alzforum. (Comment below.) Shifty Masses.

2023年9月20日 · Comparing reactive astrocyte RNA-Seq datasets from Alzheimer’s, multiple sclerosis, Huntington’s, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Parkinson’s brain revealed a single gene that is downregulated in all six: TMEM164 (center). [Courtesy of Zhang et al., Nature Metabolism.]

2022年6月30日 · A cocktail of cytokines triggers at least two opposing astrocyte reactions that balance each other. Controlled by STAT3, one churns out IL-6; the other unleashes interferons. A core group of transcriptional regulators oversees a diversity in …

First, Bellaver investigated how astrocyte reactivity influenced the relationship between amyloid status, as gauged by PET or plasma Aβ42/40 levels, and plasma p-tau217. She found that across the AD continuum, plasma p-tau217 increased as a function of plaque burden, but only if astrocytes were reactive, as gauged by elevated plasma GFAP.

2020年11月18日 · Neurofibrillary tangles develop primarily in glutamatergic pyramidal neurons and misfolded tau is thought to propagate through neural circuits trans-synaptically. Astrocyte fine processes rich in glutamate transporters are a structural and functional part of the excitatory glutamatergic synapses (Ventura and Harris, 1999). Thus, it is plausible ...