2019年11月1日 · Therefore, we developed a novel experimental model of asthma in rats using ovalbumin (OVA) and lipopolysaccharide (LPS) allergens. Rats were divided into four groups; normal (NC), OVA, LPS, and OVA-LPS treated.

2020年5月28日 · The aim of the present study was to develop an objective model of allergic asthma in atopic rats that allows the induction and quantification of anaphylactic shock with quantitative variables. Female Brown Norway rats were intraperitoneally sensitized with ovalbumin (OVA), alum and Bordetella pertussis toxin and boosted a week later with OVA in ...

Here we introduce a rat model of allergic asthma that is easy to induce, in which anaphylactic shock can be objectively quantified by changes in motor activity and body temperature, among others.

The following features of human asthma can be effectively investigated in a rat model of the disease: cellular infiltration of the lung, antigen-specific IgE production, and a predominant Th2 response. The majority of available models of asthma are restricted to the acute inflammatory response following a short period of allergen exposure.

The rat was the first experimental asthma model, but was overtaken in numbers by murine models many years ago. Data will be compiled to document that the rat model still has an important role in the research of bronchial asthma and other lung diseases.

2010年7月30日 · S100A9 caused a dose-dependent decrease in the RL in an asthma rat model, and treatment with a 0.1 μg/kg dose of S100A9 elicited the greatest relaxation response in isolated tracheal spirals. These results suggest that S100A9 reduces airway smooth muscle constriction by altering Ca 2+ signalling and by reducing the production of ROS.

2020年5月28日 · These results show an effective and relatively rapid model of allergic asthma in female Brown Norway rats that allows the quantification of the anaphylactic response. Experimental designs...

These results show an e ective and relatively rapid model of allergic asthma in female Brown Norway rats that allows the quantification of the anaphylactic response. 1. Introduction. Allergic asthma is a chronic inflammatory disorder of the airways, caused by an immunological-mediated hypersensitivity reaction [1].

Rat asthma models most commonly use OVA for sensitization and the strain most utilized is the Brown Norway rat [152,153,154,155]. There are also models described using HDM as an antigen . The HDM model has been used more recently for evaluation of treatments in the area of angiogenesis [157,158].

2023年10月5日 · A rat model of bronchial asthma was established, and the effects of Mahuang-Wuweizi were investigated using hematoxylin-eosin (HE) staining, immunohistochemistry (IHC) staining, enzyme-linked immunosorbent assay (ELISA), Western blotting (WB), and real-time reverse transcription polymerase chain reaction (RT-qPCR).