2024年12月24日 · ARHGEF2 (Rho/Rac Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with ARHGEF2 include Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations and Choreatic Disease. Among its related pathways are p75 NTR receptor-mediated signalling and GPCR Pathway.

2022年11月5日 · ARHGEF2 is transcriptionally repressed by AR, and the AR-targeted therapy relieves this repression leading to ARHGEF2 up-regulation. In addition, experiments demonstrate that ARHGEF2...

Rho GTP 酶在许多细胞过程中起着重要作用，这些过程由通过 G 蛋白偶联受体起作用的细胞外刺激物启动。 编码的蛋白质可能与 G 蛋白形成复合物并刺激 rho 依赖性信号。 已经识别出编码不同亚型的可变剪接转录本变体。 [RefSeq 提供，2009 年 6 月] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors.

2017年10月31日 · The PAR-1-MARK pathway controls cell polarity through the phosphorylation of microtubule-associated proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which activates Ras homolog family member A (RHOA), is anchored to the microtubule network and sequestered in an inhibited state throu …

Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder. Overexpression of miR-194 downregulates the GEF-H1/RhoA pathway, inhibits melanoma cancer cell …

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene. [5] [6] [7]

2024年12月28日 · 本文将详细介绍ARHGEF2基因在细胞中的表达调控机制，包括其功能、表达位置、调控方式以及与其他分子的相互作用。 ARHGEF2，也被称为 LFP40 、 GEF-H1 、 KIAA0651 、 P40 、 Lfc 和 GEFH1，是一个编码蛋白质的基因。 它位于人类基因组的 1q22 位置。 这个基因属于 Pleckstrin homology domain containing, Dbl family Rho GEFs 家族，这个家族的成员都与调控细胞内的小GTP酶（如Rho和Rac）的活性有关。 ARHGEF2的主要功能是作为 …

To test whether the genetic removal of Arhgef2 affects neurite branching and synapse formation during neural differentiation, we examined the morphology of cortical neurites and dendrite spines in adult Arhgef2−/− mice. Golgi staining demonstrated that the spine density and length were significantly below the level of those of wild-type ...

2022年7月27日 · Elevated ARHGEF2 accelerates HCC angiogenesis via the EDN1 pathway, enhances HCC cell proliferation and tumor growth both in vitro and in vivo, and contributes to ER stress-related treatment...

ARHGEF2的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为卢GTP酶在由通过G蛋白偶联受体工作外刺激引发许多细胞过程中发挥了重要作用。 所编码的蛋白质可形成复合物以G蛋白和刺激RHO依赖性信号。 另外剪接转录变体编码不同的亚型已经确定。 [由RefSeq的，2009年06月提供]