Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium; the antibiotics listed are active against E.faecalis, but have limited activity for E.faecium Cloxacillin and clindamycin typically have less than 40% activity for S.epidermidis, thus usage depends on local susceptibility data

ANTIBIOTIC SENSITIVITY CHART Created by James McCormack, BSc(Pharm), PharmD and Fawziah Lalji, BSc(Pharm), PharmD, with assistance from Drs. Tim Lau, Cesilia Nishi, Solomon Chow Faculty of Pharmaceutical Sciences, University of British Columbia, and Vancouver Hospital, Vancouver, BC Gram Positive Cocci Anaerobes Streptococci Gram Negative Bacilli

This booklet contains up-to-date information to assist in decisions concerning antimicrobial therapy. Tables summarize susceptibility data obtained for organisms isolated in the VUMC Clinical Microbiology Laboratory between January 1, 2023 – December 31, 2023. Guidelines for Interpretation of Minimum Inhibitory Concentrations (MICs)

antibiotic sensitivity chart Created by James McCormack, BSc(Pharm), Pharm D and Fawziah Lalji, BSc(Pharm), PharmD, FCSHP with help from Michael Legal and Tim Lau

Activity of selected antibiotics against gram-positive cocci. Staphylococci resistant to oxacillin (methicillin) are also resistant to penicillin, ampicillin, cefazolin, cefoxitin, ceftriaxone, meropenem and all other beta-lactam antibiotics. Staphylococci species breakpoints are in use.

Levofloxacin breakpoints for Pseudomonas aeruginosa are based on a dosage regimen of 750mg every 24 hours. Piperacillin/tazobactam and Cefepime results include Susceptible Dose Dependent (SDD) isolates.

Activity of selected antibiotics against gram-positive cocci. Staphylococci resistant to oxacillin (methicillin) are also resistant to penicillin, ampicillin, cefazolin, cefoxitin, ceftriaxone, meropenem and all other beta-lactam antibiotics. Staphylococci species breakpoints are in use.

This chart is based on 2015 UW Medicine antibiogram (>70% suscpetibility highlighted) and is intended as an initial guidance, and should not replace clinical judgement Amoxicillin Gram Negative Bacilli

supports rapid and accurate quantitative antibiotic susceptibility test (AST) reporting, including minimum inhibitory concentration (MIC). The MIC provides the ability to precisely determine the concentration of antibiotic required to inhibit growth of a pathogen.

ANTIBIOTIC SUSCEPTIBILITIES IN INTENSIVE CARE* For simplicity, atypical organisms are not included above. Partial columns indicate incomplete coverage. ESBL-producing organisms are not susceptible to most antibiotics containing a beta-lactam ring; carbapenems are the usual agent of choice.