Mouse anti anthrax antibody, clone 7821 recognizes the protective antigen (PA) of Bacillus anthracis, also known as the toxin binding protein, a component, along with edema factor and lethal factor, of the anthrax toxin.

The anthrax protective antigen (PA) is the central component of the three-part anthrax toxin, and it is the primary immunogenic component in the approved AVA anthrax vaccine and the “next-generation” recombinant PA (rPA) anthrax vaccines.

Immunohistochemistry on Paraffin Sections (1/10-1/50). This antibody is specific for the Protective Antigen (PA) of Bacillus Antracis, which is a component of the Anthrax toxin. Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Anthrax can initiate via cutaneous, gastrointestinal, and inhalation inoculation, with the last two causing significant mortality. The spore is the infectious particle and is notable for being metabolically dormant and resistant to host-mediated killing and common disinfectants (1).

2006年5月15日 · The 2001 anthrax attacks demonstrated a need for fast, dependable methods for detecting Bacillus anthracis spores in vitro and in vivo. We have developed a variety of isotypes and specificities of mAbs that were able to distinguish B. anthracis spores from other Bacillus spores. The majority of Abs were directed toward BclA, a major component ...

2010年2月28日 · The epidemic under study was characterized by a single anthrax clone. Although the epidemic spread over a large area, it involved extremely closely related isolates, 86.7% of which (SGT-1) were identical across the highly discriminating SNR markers.

2012年7月1日 · Here, we present a rapid and highly efficient method of sample preparation that enables specific separation of B. anthracis (Sterne) spores from food at concentrations as low as 1 CFU/ml.

2010年2月28日 · The analysis revealed the prevalent spread, during this epidemic, of a single anthrax clone. SGT-1--widely distributed across the epidemic area and present throughout the period in question - may, thus, be the ancestral form. SGTs 2, 3 and 4 differed from SGT-1 at only one locus, suggesting that the …

2001年11月8日 · We have identified a 368-amino-acid human protein, ATR, that contains a single extracellular VWA/I domain and serves as the cellular receptor for anthrax toxin. The clone that encodes this...

The anthrax protective antigen (PA) is the central component of the three-part anthrax toxin, and it is the primary immunogenic component in the approved AVA anthrax vaccine and the "next-generation" recombinant PA (rPA) anthrax vaccines. Animal models have indicated that PA-specific antibodies (AB) …