ANP32A Gene - GeneCards | AN32A Protein | AN32A Antibody
2025年3月30日 · ANP32A (Acidic Nuclear Phosphoprotein 32 Family Member A) is a Protein Coding gene. Diseases associated with ANP32A include Influenza and Primary Cerebellar Degeneration. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Processing of Capped Intron-Containing Pre-mRNA.
揭示宿主因子ANP32A介导流感病毒复制酶的组装 - 网易
2020年11月19日 · 这些结构揭示了流感病毒复制酶（Replicase）如何组装，以及宿主因子ANP32A如何介导流感病毒基因复制。 在FluPol-ANP32A复合物的结构中，ANP32A蛋白介导两个FluPol分子组装成一个不对称的二体结构（图2）。
Species difference in ANP32A underlies influenza A virus ... - Nature
2016年1月6日 · We show that a species-specific difference in host protein ANP32A accounts for the suboptimal function of avian virus polymerase in mammalian cells. Avian ANP32A possesses an additional 33...
Creating resistance to avian influenza infection through ... - Nature
2023年10月10日 · In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited (GE) chickens containing two ANP32A amino acid substitutions that...
Host ANP32A mediates the assembly of the influenza virus replicase
2020年11月18日 · Here we report cryo-electron microscopy structures of influenza C virus polymerase (FluPolC) in complex with human and chicken ANP32A. In both structures, two FluPolC molecules form an asymmetric...
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene. [5] [6] [7] It is one of the targets of an oncomiR, MIRN21.
Avian ANP32A incorporated in avian influenza A virions promotes …
2024年1月31日 · Species-specific differences in acidic nuclear phosphoprotein 32 family member A (ANP32A) determine the restriction of avian-signature polymerase in mammalian cells. Mutations that evade this restriction, such as PB2-E627K, are frequently acquired when avian influenza A viruses jump from avian hosts to mammalian hosts.
哈兽研发现流感病毒聚合酶复制必需的宿主因子及其作用机制-综合 …
2019年4月23日 · 近日，我所兽医生物技术国家重点实验室王晓钧团队首次证明了宿主因子ANP32A/B是A型流感病毒聚合酶发挥功能所必需的宿主因子，并揭示了其与聚合酶相互作用的关键位点。 该研究成果以“Fundamental contribution and host range determination of ANP32A and ANP32B in influenza A virus polymerase activity”为题发表于《病毒学杂志（Journal of Virology）》。 流感病毒的RNA聚合酶是由PB1、PB2、PA三个聚合酶亚基组成的复合体，是 …
Roles of ANP32 proteins in cell biology and viral replication
2022年10月11日 · ANP32 family proteins regulate a variety of physiological functions, including chromatin remodeling, apoptosis and nervous system development. Abnormal ANP32 expression is closely related to tumorigenesis.
ANP32A acidic nuclear phosphoprotein 32 family member A
Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A). Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.