2021年5月7日 · Amorisin | C30H36O6 | CID 16727161 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

依西美坦 （INN: exemestane，商品名Aromasin，台灣譯名諾曼癌素）是治療 乳癌 的抗雌激素藥物，屬於芳香化酶抑制劑。 某些乳癌細胞具有雌激素 受体 （ER），受 雌激素 刺激而生長，被稱為ER陽性（或稱雌激素反應性、激素反應性或激素受體陽性乳癌）。 芳香化酶 是合成雌激素的 酶，使用其抑制劑可阻止雌激素的合成，以減緩腫瘤的生长。 依西美坦的適應症是治療停經後雌激素受體陽性早期乳癌病人，術後曾接受過tamoxifen治療二至三年，可轉用本藥完成共計五年的 …

用于经他莫昔芬辅助治疗2－3年后，绝经后雌激素受体阳性的妇女的早期浸润性乳腺癌的辅助治疗，直至完成总共5年的辅助内分泌治疗。 早期乳腺癌患者在接受2-3年的他莫昔芬治疗后，在未出现复发或对侧乳腺癌的情况下，应使用本品继续治疗，直至完成5年的联合序贯辅助内分泌治疗（即他莫昔芬序贯依西美坦）。 合并使用细胞色素P-450 (CYP) 3A4的强诱导剂会降低依西美坦暴露量。 患者同时接受CYP 3A4强诱导剂，如利福平、苯妥英时，本品的推荐剂量为50 mg，每日一 …

2024年8月23日 · Exemestane (brand name Aromasin) is an aromatase inhibitor used to lower estrogen levels in women past menopause with early or advanced hormone-sensitive breast cancer. Early breast cancer is cancer that has not spread outside the breast. Advanced breast cancer is cancer that has spread to other parts of the body.

2024年12月2日 · Aromasin is used to treat early and advanced breast cancer in postmenopausal women. Early breast cancer is cancer that has not spread outside the breast. Advanced breast cancer is cancer that has spread to other parts of the body.

- Abstract--- Three novel flavanones, amoritin, amorisin, and amorilin were isolated from the root bark of Amorpha fruticosa L. Their structures were determined on the basis of chemical and spectroscopic evidences. The crude extracts and some flavonoid components of the fruit of Amorpha fruticosa L.(Leguminosae) 5,6

2011年8月1日 · Based on activity-guided fractionation, the acetone extract of Amorpha fruticosa roots gave four flavanones 1–4 and three rotenoids 5–7 which were identified as amoradicin (1), amorisin (2), isoamoritin (3), amoricin (4), amorphigeni (5), dalbinol (6), and 6-ketodehydroamorphigenin (7), respectively.

1984年1月1日 · In particular, amorisin 2 exhibited 120 nM IC 50, which is 30-fold more potent than the positive control, quercetin. In addition, this is the first report detailing rotenoids (IC 50 = 8.34–16.74 μM) exhibiting neuraminidase inhibition. Kinetic analysis revealed that all inhibitors were noncompetitive.

All isolated inhibitors showed strong neuraminidase inhibition with IC₅₀s between 0.12 and 22.03 μM. In particular, amorisin 2 exhibited 120 nM IC(₅₀, which is 30-fold more potent than the positive control, quercetin. In addition, this is the first report detailing rotenoids (IC₅₀ = 8.34-16.74 μM) exhibiting neuraminidase inhibition.

2009年3月2日 · scientific article published on 2 March 2009. Amoritin, Amorisin, and Amorilin: Three New Phenylated Flavanones from Amorpha fruticosa L. (Q104991752)