The alphaviruses are small, spherical, enveloped viruses with a genome of a single strand of positive-sense RNA. The total genome length ranges between 11,000 and 12,000 nucleotides, and has a 5’ cap and a 3’ poly-A tail.

Alphavirus is one of two genera in the family Togaviridae; Rubivirus (rubella virus), the other togavirus genus, is discussed in Chapter 55. The 27 alphaviruses are classified on the basis of antigenic properties.

Alphaviruses affect host immunity through cytokines and the interferon response. Understanding alphavirus interactions with both the innate immune system as well as the various cells in the adaptive immune systems is critical to developing effective therapeutics.

Alphaviruses are positive sense, single stranded, RNA viruses in the family Togaviridae, which are classified as members of the domain Riboviria 1. The alphaviruses currently encompass more than thirty members that infect a wide range of host …

Alphaviruses belong to the Togaviridae family and are small, enveloped viruses with a single-stranded positive-sense RNA genome. This genome is approximately 11.7 kb in length and encodes for a limited number of proteins, which are crucial for …

Human alphaviral disease presents with either arthritogenic or encephalitic manifestations and is associated with significant morbidity and/or mortality. Unfortunately, there are presently no vaccines or antiviral measures approved for human use.

2022年12月6日 · Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human infection and disease on a global scale. These viruses are classified as either arthritogenic or encephalitic based...

Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway, including attachment, internalization, and fusion.

Alphaviruses are zoonotic pathogens that are maintained primarily in rodents, primates, and birds by mosquito vectors, although a few infect fish and seals and may have no arthropod vector.

2025年1月25日 · Alphaviruses are infectious agents that replicate in humans and many animals; this viral genus includes Chikungunya virus, Semliki Forest virus and Sindbis virus. Alphaviruses are transmitted...