2016年1月1日 · ALDH1B1 is mainly involved in the detoxification of alcohol-derived acetaldehyde, aside other roles in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Bioinformatics analysis suggests that about 16 amino acid residues of this protein are extremely hyperacetylated.

Aldehyde dehydrogenase 1 family, member A2, also known as ALDH1A2 or retinaldehyde dehydrogenase 2 (RALDH2), is an enzyme that in humans is encoded by the ALDH1A2 gene. [5][6] ALDH1a2 belongs to the aldehyde dehydrogenase family …

2024年12月24日 · ALDH1A2 (Aldehyde Dehydrogenase 1 Family Member A2) is a Protein Coding gene. Diseases associated with ALDH1A2 include Diaphragmatic Hernia 4, With Cardiovascular Defects and Renal Hypodysplasia/Aplasia 1. Among its related pathways are Signaling by Retinoic Acid and ESR-mediated signaling.

2018年2月9日 · In this study, we used RNA sequencing data from The Cancer Genome Atlas (TCGA) to evaluate the differential expression of 19 ALDH isoforms in 5 common human cancers. The 19 ALDH genes were analyzed...

醛脱氢酶1家族成员A2（英語： Aldehyde dehydrogenase 1 family, member A2），简称为ALDH1A2，或称为 视黄醛 脱氢酶2（简写为RALDH2），是在人体内一种由ALDH1A2 基因 编码的 酶。 [5][6]此蛋白为醛脱氢酶蛋白家族成员，是负责 催化 视黄酸 到 视黄醛 的合成的 酶。 视黄酸 是 维生素A （即视黄醇）的活性衍生物，是一种 旁分泌 激素 信号分子，主要作用于发育中的组织和成年组织中。 [7]对小鼠中类似基因的研究表明，这种酶和 细胞色素 CYP26A1同时确立 …

2011年5月1日 · Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation of molecules that are important in cellular processes, like retinoic acid, betaine and gamma-aminobutyric acid.

视黄酸是维生素 A (视黄醇) 的活性衍生物，是一种激素信号分子，在发育和成人组织中发挥作用。 对类似小鼠基因的研究表明，这种酶和细胞色素 CYP26A1 同时建立局部胚胎视黄酸水平，促进后部器官发育并预防脊柱裂。 已经为该基因鉴定了编码不同亚型的四种转录物变体。 [RefSeq 提供，2011 年 5 月] This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an Enzyme that catalyzes the synthesis of retinoic acid (RA) from …

2022年7月4日 · We have discovered selective inhibitors of ALDH1B1, a mitochondrial enzyme that promotes colorectal and pancreatic cancer. We describe bicyclic imidazoliums and guanidines that target the ALDH1B1...

2018年3月19日 · ADH1B和ALDH2分别是ADH和ALDH的2个重要亚型。 ADH 1 B 和 ALDH 2基因多态性与多种疾病,如消化系统疾病、神经退行性变及代谢性疾病等相关。 文章对 ADH 1 B 及 ALDH 2基因多态性与相关疾病的关系进行综述,以期为疾病的预防和诊断提供新的思路。 Alcohol dehydrogenase （ADH） and aldehyde dehydrogenase （ALDH）are key enzymes of alcohol metabolism in human liver,which constitute ethanol dehydrogenase oxidation system.

In tumors, evidence points to that ALDHs such as ALDH1A1, ALDH1A3, and ALDH3A1 are critical drivers of chemotherapeutic and radiotherapeutic resistance in many solid tumors by detoxifying cytotoxic drugs and mitigating oxidative stress. 23, 27 For example, silencing of the ALDH1A1 gene in human breast cancer cells increases their sensitivity to ...