2024年12月24日 · ALDH1B1 (Aldehyde Dehydrogenase 1 Family Member B1) is a Protein Coding gene. Diseases associated with ALDH1B1 include Mitochondrial Disease and Epilepsy. Among its related pathways are Oxidation by cytochrome P450 and Metabolism of proteins.

2022年7月4日 · We have discovered selective inhibitors of ALDH1B1, a mitochondrial enzyme that promotes colorectal and pancreatic cancer. We describe bicyclic imidazoliums and guanidines that target the...

醛脱氢酶是酒精代谢的主要氧化途径中的第二种酶。 该基因在编码序列中不包含内含子。 该基因座的变异可能会影响酒精相关问题的发展。 [RefSeq 提供，2008 年 7 月] This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second Enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence.

2022年7月11日 · 在这项最新研究中，研究团队开发了一种 aldh1b1 选择性抑制剂——iguana-1， 这是一种胍类和咪唑类小分子化合物，这两种药效团都能靶向 aldh1b1 活性位点并抑制其功能，而且，胍类还避免了咪唑类所表现出的脱靶线粒体毒性。

2025年1月4日 · ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding. Our findings provide clear evidence for both individual and interactive associations of ALDH1b1 and ALDH2 genes with the development of coronary artery disease in Han Chinese.

Aldehyde dehydrogenase X, mitochondrial is an enzyme that in humans is encoded by the ALDH1B1 gene. [5][6] This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence.

2017年9月7日 · We recently reported that ALDH1B1, which has functional roles in tumourigenesis, may be a better CRC marker than ALDH1A1. Human CRC explants and cell lines were analysed to identify candidate CRC...

2011年2月11日 · ALDH1B1 is a mitochondrial ALDH that metabolizes a wide range of aldehyde substrates including acetaldehyde and products of lipid peroxidation (LPO).

2021年1月6日 · Taken together, ALDH1B1 confers alterations in the cell morphology, cell cycle progression and gene expression, accompanied by significant changes in the chemosensitivity and migratory potential of HT29 cells, underlying its potential significance in cancer progression.

2022年7月11日 · 在这项最新研究中，研究团队开发了一种 aldh1b1 选择性抑制剂——iguana-1，这是一种胍类和咪唑类小分子化合物，这两种药效团都能靶向 aldh1b1 活性位点并抑制其功能，而且，胍类还避免了咪唑类所表现出的脱靶线粒体毒性。