Alcohol is more toxic in the ageing organism because of changes in its metabolism, distribution and elimination, which lead to central nervous system effects at lower levels of intake; also, …

2025年1月10日 · The risk of having MetS is higher with substantial or excessive alcohol use: a mild alcohol intake with 100–300 kcal/day can contribute directly to weight gain and obesity, …

Alcohol is eliminated from the body by various metabolic mechanisms. The primary enzymes involved are aldehyde dehydrogenase (ALDH), alcohol dehydrogenase (ADH), cytochrome …

Alcohol is metabolized by several processes or pathways. The most common of these pathways involves two enzymes—alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). …

This article summarizes recent experimental and epidemiological data on the toxic and beneficial effects of ethanol and its metabolites (acetaldehyde), and focuses on their immunomodulatory …

2024年6月20日 · Here we show that a liver–gut axis, rather than liver alone, synergistically drives systemic AcH clearance and voluntary alcohol drinking. Mechanistically, we find that after …

2024年6月27日 · 近期，高斌团队最新研究发现，除了肝脏之外的多个器官（包括肠道）中选择性敲除Aldh2并未或仅略微提高血清AcH水平，而同时删除肝脏和肠道中的Aldh2则能起到协同作 …

Heavy alcohol drinking increases the risk of cardiovascular and liver disease, metabolic disturbances, nutritional deficiencies, cancers (i.e. mouth, stomach, colon, liver and breast …

Gas fermentation using acetogenic bacteria such as Clostridium autoethanogenum offers an attractive route for production of fuel ethanol from industrial waste gases. Acetate reduction to …

Alcohol abuse disrupts multiple cellular mechanisms, leading to altered organ function and disease. Among the most im-portant pathophysiological mechanisms identified as caus-ative …