2025年3月30日 · This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in …

2021年10月1日 · Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM can be proteolytically cleaved at the cell surface by metalloproteases, which generate shedding of its ectodomain.

该基因编码活化的白细胞细胞粘附分子 (alcam) ，也称为 cd166 (分化簇 166) ，它是免疫球蛋白受体亚家族的成员，在胞外域中具有五个免疫球蛋白样结构域 (vvc2c2c2) 。

2020年8月1日 · Activated leukocyte cell adhesion molecule (ALCAM) or CD166 is a 100 to 105 KDa transmembrane immunoglobulin which is involved in activation of T-cells, hematopoiesis, neutrophils trans-endothelial migration, angiogenesis, inflammation and tumor propagation and invasiveness through formation of homophilic and heterophilic interactions.

白细胞活化黏附因子（ALCAM，Activated Leukocyte Cell Adhesion Molecule）是一种重要的细胞黏附因子，属于免疫球蛋白超家族。 ALCAM主要存在于多种细胞类型中，如白细胞、 内皮细胞 和 上皮细胞 等，对免疫系统的功能和细胞之间的相互作用起着关键作用。 ALCAM由570个氨基酸构成，这些氨基酸形成了5个细胞间免疫球蛋白样结构域。 这些结构域能够与自身或其他蛋白（如 CD6）结合，从而实现细胞间的相互作用。 在内皮细胞内，分泌型的ALCAM只由437个氨基 …

2025年2月8日 · This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in …

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. [5][6] It is also called CD166 (cluster of differentiation 166), MEMD, [7] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a member of the immunoglobulin superfamily and belongs to a recent subgroup with five extracellular immunoglobulin-like domains (VVC2C2C2). ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions.

Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a cell–cell adhesion protein conferring heterotypic and homotypic interactions between cells of the same type and different types. It is aberrantly expressed in various cancer types and has been shown to be a regulator of cancer metastasis.

2023年1月3日 · Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a cell–cell adhesion protein conferring heterotypic and homotypic interactions between cells of the same type and different types. It is aberrantly expressed in various cancer types and has been shown to be a regulator of cancer metastasis.