PIP3激活PDK1，PDK1在Thr308位点磷酸化AKT。AKT也可被PDK2在Ser473位点磷酸化并激活。激活的AKT可通过与许多下游信号分子相互作用来调节多种细胞生物学功能，如p21、p27、TGFβ、ataxin-1、GABA受体、Bad、NF-κB和mTOR。 三、PI3K-AKT信号通路的组成 PI3K-Akt信号通路. 1、PI3K

2015年12月21日 · Our results show that solamargine inhibits the growth of human lung cancer cells through inactivation of Akt signaling, followed by reduction of SP1 and p65 protein expression. This results in the inhibition of EP4 gene expression.

2020年8月1日 · Inhibition of integrin αVβ5 remarkably reversed the expression of VEGFR2 and phosphorylation level of Akt in HUVECs grown on higher stiffness substrate. Except that, PI3K inhibitor also suppressed the phosphorylation level of Akt and the expressions of VEGFR2 and nuclear Sp1 evidently.

2020年8月1日 · Our results showed that PI3K inhibitor suppressed the expression nuclear Sp1 significantly, simultaneously attenuated the phosphorylation level of Akt and the expressions of VEGFR2. Taken all together, higher matrix stiffness upregulates VEGFR2 expression in HUVECs via activating αVβ5/Akt-Sp1 pathway.

2015年12月21日 · Our results show that solamargine inhibits the growth of human lung cancer cells through inactivation of Akt signaling, followed by reduction of SP1 and p65 protein expression. This results in the inhibition of EP4 gene expression. The cross-talk between SP1 and p65, and the positive feedback regula …

转录因子SP1（Specificity Protein 1）与多条信号通路相关，主要包括以下几种： MAPK信号通路 ：SP1可以被MAPK家族的激酶（如ERK、JNK和p38）磷酸化，从而调节其转录活性。

Sp1和PI3K／Akt信号通路关键蛋白的表达；采用PI3K特异性抑制剂LY294002处理细胞或转染Sp1的干扰序列至 细胞中，以验证PI3K／Akt／Sp1信号通路在肠道H 2 S产生过程中的调控作用。

2022年10月5日 · This review presents data on the involvement of Sp1 in the regulation of the expression of genes encoding components of the MAPK, p38, JAK/STAT, and PI3K/Akt signaling pathways, as well as how the activity of these signaling cascades is associated with the transcriptional activity of the Sp1 protein in human and animal cells in normal ...

2004年9月1日 · Using both adenoviral vectors and a cell line permanently expressing constitutively active myristoylated Akt (myrAkt), we show that activation of Akt, which is downstream of PI3K, increases VEGF expression in vitro and increases angiogenesis in a Matrigel plug assay.

本综述介绍了 Sp1 转录因子与 MAPK、p38、JAK/STAT 和 PI3K/Akt 信号通路在正常组织和各种病理（包括恶性疾病）中的活性之间关系的数据。 Sp1 是 Sp/KLF 家族的转录因子，可与基因调控区域中富含 GC 的基序结合。 Sp1参与细胞增殖、凋亡和分化以及血管生成的调节。 在肺癌、乳腺癌、胰腺癌、甲状腺癌、胃癌和神经胶质瘤等肿瘤疾病的细胞中发现了高水平的 SP1 表达，以及由于翻译后修饰而导致的异常转录活性。 先天性心脏病，以及神经退行性疾病，包括亨廷顿病 …