在肿瘤的发生发展过程中PI3K/AKT/mTOR信号通路的激活是导致肿瘤细胞生长、发展 、增殖 、转移特别是EMT 失调的重要原因。 本文主要针对细胞EMT 与PI3K/AKT/mTOR信号转导通路之 …

在TGF-β信号介导的非Smad信号通路中，它可以激活PI3K-AKT-mTOR信号进行转录调控，而活化的AKT也可以通过抑制核糖核蛋白E1（hnrnpe1）进行转录调控从而达到触发EMT的效果。

Specifically, the PI3K/Akt signaling pathway can affect the EMT in a variety of ways to influence tumor aggressiveness. A better understanding of the regulatory mechanisms related to the …

2023年8月14日 · It has been shown that PI3K/AKT pathway can induce the EMT process by down regulation of epithelial markers, while up regulation of mesenchymal markers and EMT …

2015年8月5日 · The epithelial-mesenchymal transition (EMT) is an orderly, polygenic biological process that plays an important role in tumor cell invasion, metastasis and chemoresistance. …

Several molecular mechanisms promote EMT, Including regulation of the levels of specific cell-surface proteins, ECM-degrading enzymes, and altering the expression of certain transcription …

2021年10月19日 · PLCB1 激活 PI3K/AKT 信号通路诱导 CCA 细胞进行上皮 - 间充质转化 (EMT)。 在机制上， PABPC1 与 PLCB1 和 PI3K 相互作用，通过 PI3K/AKT/GSK-3β/Snail 信号放大 …

2005年11月14日 · Recently, activation of the phosphatidylinositol 3′ kinase (PI3K)/AKT axis is emerging as a central feature of EMT. In this review, we discuss the role of PI3K/AKT …

2019年10月1日 · Several studies suggest that in the process of phosphorylation, Akt/mTOR signaling pathway induces EMT in cancer cells by activating the transcription factors involved …

Here, we show that PRMT5 is the ectopic expression in human lung cancer tissues and cell lines. Further study reveals that silencing PRMT5 by lentivirus-mediated shRNA or blocking of …