THE ROLE OF ACUTE KIDNEY INJURY IN CHRONIC KIDNEY DISEASE
Underlying CKD is now recognized as a clear risk factor for AKI, as both decreased glomerular filtration rate (GFR) and increased proteinuria have each been shown to be strongly associated with AKI. A growing body of literature also provides …
AKI on CKD: heightened injury, suppressed repair, and the …
Acute kidney injury (AKI) and chronic kidney disease (CKD) are inter-connected. While AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very limited. Nonetheless, AKI, when occurring in CKD patients, is known to …
Acute kidney injury and chronic kidney disease: from the laboratory …
With improved sample size, assessment criteria and length of follow-up there are now strong data in support of three findings that: 1) pre-existing CKD is a major risk factor for the development of AKI (8 - 10); 2) patients with CKD who develop AKI often recover incompletely and experience worsened subsequent renal deterioration (8, 11, 12); and...
Transition from acute kidney injury to chronic kidney disease ...
2024年9月19日 · AKI often progresses to CKD due to maladaptive repair processes, persistent inflammation, and fibrosis, with both conditions sharing common pathways involving cell death, inflammation, and extracellular matrix (ECM) deposition.
The Road from AKI to CKD: Molecular Mechanisms and …
2023年7月13日 · Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a precipitous decline in renal function. In recent years, a growing body of studies have demonstrated...
Transition from Acute Kidney Injury to Chronic Kidney Disease ...
2024年9月19日 · Acute kidney injury (AKI) and chronic kidney disease (CKD) are increasingly recognized as interconnected conditions with overlapping pathophysiological mechanisms. This review examines the transition from AKI to CKD, focusing on the molecular mechanisms, animal models, and biomarkers essential for understanding and managing this progression.
Pathophysiology of AKI to CKD progression - Seminars in …
AKI is associated with significant morbidity and subsequent chronic kidney disease (CKD) development. Regardless of the initial insult, CKD progression after AKI involves multiple types of cells, including proximal tubular cells, fibroblasts, and immune cells.
Acute Kidney Injury to Chronic Kidney Disease Transition
Potential therapeutic approaches to treat AKI and block the transition to CKD/ESRD have been recently reported, but they need further validations. Key Messages: Maladaptive repair after AKI is strongly associated to the development of CKD and long-term consequences.
From AKI to CKD: Maladaptive Repair and the Underlying …
2022年8月15日 · Acute kidney injury (AKI) is defined as a pathological condition in which the glomerular filtration rate decreases rapidly over a short period of time, resulting in changes in the physiological function and tissue structure of the kidney.
AKI can cause end-stage renal disease (ESRD) directly, and increase the risk of developing incident chronic kidney disease (CKD) and worsening of underlying CKD. In addition, severity, duration, and frequency of AKI appear to be important predictors of poor patient outcomes.
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