2023年11月25日 · Identify the risk factors and clinical indicators associated with acute kidney injury to facilitate early recognition and intervention. Differentiate between prerenal, intrinsic renal, and postrenal causes of acute kidney injury, utilizing diagnostic tools and clinical assessment to guide appropriate treatment strategies.

Recently, growing evidence emphasizes T lymphocytes role in affecting AKI pathogenesis and magnitude. In particular, T helper 17 lymphocytes enhance tissue injury by recruiting neutrophils and other inflammatory cells, while regulatory T cells …

本指南针对AKI诊治的6大类临床问题，系统介绍了AKI的定义及流行病学特点、AKI的诊断与监测、AKI的非血液净化治疗、AKI的肾脏替代治疗策略、特殊人群AKI诊治及AKI的转归和预后，旨在系统规范我国AKI的诊疗，为中国AKI的诊治提供第一个全面、系统性的指导性文件。 基于保证本指南的科学性、权威性和公正性，国家慢性肾病临床医学研究中心联合中国医师协会肾脏内科医师分会组建了由肾脏病、泌尿外科和血液净化专家组成的指南编写小组，由陈香美院士担任组长，编 …

Here we review the mechanisms of ischemic AKI, focusing on the role of T cells during the injury phase and recovery process based on experimental studies, emphasizing recent literature. Studies using murine ischemia-reperfusion injury (IRI) models have provided the most mechanistic evidence of T cells in ischemic AKI (Table 1) [7, 9, 16 – 42].

2023年6月22日 · T cells play an important role in acute kidney injury (AKI). Metabolic programming of T cells regulates their function, is a rapidly emerging field, and is unknown in AKI. We induced ischemic AKI in C57BL/6J mice and collected kidneys and spleens at …

2020年3月1日 · Summary: Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of …

2024年9月1日 · Chimeric antigen receptor T cell (CAR-T) therapy is a promising treatment for hematologic tumors, and adverse events of acute kidney injury (AKI) have been reported. However, its incidence, clinical characteristics, and prognosis remained unclear.

2025年3月22日 · Acute kidney injury (AKI) is a clinical challenge characterized by elevated morbidity and a substantial impact on individual health and socioeconomic factors. A comprehensive examination of the molecular pathways behind AKI is essential for its prevention and management. In recent years, vigorous research in the domain of AKI has concentrated on pathophysiological characteristics, early ...

2024年9月3日 · 急性肾损伤（Acute kidney injury, AKI）是临床常见的急危重症，不仅会引起严重的急性机体内环境紊乱而威胁患者生命，研究还发现，AKI进展为慢性肾脏病（CKD）的风险显著增加，是CKD形成和终末期肾病发生的重要原因，由于其确切诱发机制尚不清楚，因而成为肾脏 ...

2025年3月5日 · Acute kidney injury (AKI) is a critical condition with diverse manifestations and variable outcomes. Its diagnosis traditionally relies on delayed indicators such as serum creatinine and urine output, making early detection challenging. Early identification is essential to improving patient outcomes, driving the need for novel biomarkers. Recent advancements have …