Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure. [1] It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Raunatin, Saltucin Co, Salvalion, and ...

Ajmalicine is a monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist and a vasodilator agent.

Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α 1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC 50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity.

阿义马林（Ajmaline），别名阿马灵、西萝芙木碱，是一种从蛇根萝芙木中提取生物碱。 分子式为C20H26N2O2 ，分子量为326.43300。 阿义马林为抗心律失常药，临床上主要用于治疗室性心律失常和室上性心律失常、预激综合征伴室上速早搏、预激综合征伴房性早搏和预激综合征伴室性早搏。 片剂：每片50mg。 针剂：每支50mg。 具有Ⅰa类的药理作用 [2]。 口服吸收迅速，但生物利用度低。 通常给药后20分钟左右起效，40～60分钟作用最大。 阿义马林主要在肝内代谢，随 …

Ajmalicine is used as an antihypertonic, sedative and tranquilizer. It also increases the supply of oxygen to cerebral tissues and is beneficial to post-stroke rehabilitation. The plant genus Rauvolfia proved to be an excellent source of indole alkaloids that were extensively used for about two decades, before they were largely overtaken by ...

阿马碱是白色或微黄色粉末。 易溶于 三氯甲烷，微溶 乙醇 或丙酮，不溶于水。 英文别名： Raubasine;methyl 19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate;methyl (19alpha)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate; 本品为白色或微黄色粉末;无臭，风趣。 比旋度 取本品，精密称定，加三录甲烷融化并浓缩制成每1ml中含2.5mg的溶液，依法测定， 比旋度为－57°至－67° [1] 阿马碱是白色或微黄色粉末。 易溶于三氯甲烷，微溶乙醇或丙酮，不 …

中文名:阿吗碱,英文名:Ajmalicine,CAS:483-04-5,化学式:C21H24N2O3,分子量:352.43,密度:1.1823 (rough estimate),熔点:258°C (rough estimate),沸点:486.04°C (rough estimate),闪点:270.7°C,蒸汽压:4.47E-11mmHg at 25°C,折射率:1.6500 (estimate),MSDS.

The present study explores multi-target directed ligand approach using secondary metabolite reserpine (RES) and ajmalicine (AJM) obtained from Rauwolfia serpentina roots. Novel LCMS and HPLC methods were developed for identification and quantification of reserpine and ajmalicine.

阿马里辛碱是一种化学物质。 阿马里辛碱 ajmalicine 相对分子质量：352.42.咔啉类生物碱。 从甲醇中获棱柱体结晶。 mp257℃（分解）。 从萝芙木植物中分离提取。 盐酸盐从乙醇中获叶状结晶，mp290℃（分解），微溶于水和稀盐酸。 阿马里辛碱是一种化学物质。

2023年12月8日 · According to our results, AJM promoted the pyroptosis of H22 cells, increased the pyroptosis rate, and upregulated the expression of inflammatory factors tumor necrosis factor α, interleukin-1β, and interleukin-6. At the same time, it enhanced the openness of membrane pores and increased the expression of ROS.