AIFM1 is expressed as a 613- residue precursor protein that containing a mitochondrial targeting sequence (MTS) at its N-terminal and two nuclear leading sequences (NLS). Once imported …

2024年12月24日 · AIFM1 (Apoptosis Inducing Factor Mitochondria Associated 1) is a Protein Coding gene. Diseases associated with AIFM1 include Combined Oxidative Phosphorylation …

Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this regard, a large number of studies have elucidated AIF's …

AIFM1基因概述. AIFM1基因，也被称为AIF（apoptosis inducing factor），是一个与细胞凋亡密切相关的基因。它位于X染色体（Xq26.1），属于Flavoproteins家族。AIFM1基因编码的蛋白质 …

AIFM1 variants associated with auditory neuropathy spectrum disorder cause apoptosis due to impaired apoptosis-inducing factor dimerization. AIFM1 is a component of the mitochondrial …

该基因的突变导致联合氧化磷酸化缺陷 6 (COXPD6) ，一种严重的线粒体脑肌病，以及 Cowchock 综合征，也称为 X 连锁隐性 Charcot-Marie-Tooth 病 4 (CMTX-4) ，一种导致神经病变、轴突 …

Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this regard, a large number of studies have elucidated AIF's …

Brain imaging shows white matter abnormalities consistent with hypomyelinating leukodystrophy. Showing features for mutagenesis, natural variant. Increases protein dimerization at lower …

The AIFM1 gene encodes a mitochondrial flavin adenine dinucleotide (FAD)-dependent oxidoreductase that plays a role in oxidative phosphorylation (OxPhos) and redox control in …

2023年4月25日 · Here, we report that AIFM1 facilitates STING activation-induced cell apoptosis in T lymphocytes. Mechanistically, AIFM1 is upregulated after STING activation in T cells but not …