007909 - Ai9 or Ai9(RCL-tdT) Strain Details - The Jackson Laboratory
This strain is congenic on the C57BL/6J genetic background. The Ai9 allele is very similar in design to the Ai14 allele (Stock No. 007914 ) - differing only in the presence (Ai9) or absence …
Ai9 mouse | SCGE Toolkit
Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector. Testing …
Ai9 Cre Reporter Mouse Strain and Study Plans for AAV Local …
A panel of 18 natural and engineered AAV variants was screened in a murine fracture model where vector-encoded Cre recombinase expression was detected via fluorescent tdTomato …
工具鼠的工具鼠，Reporter 鼠简介 - 知乎 - 知乎专栏
常见的有 TdTomato鼠 、 mT/mG鼠 、 LacZ鼠 、彩虹鼠 等，他们的重要作用是对各种特异性表达的Cre工具鼠进行验证，简而言之就是“工具鼠的工具鼠”：前面我们关于 Cre-loxp系统 的介绍 …
Ai9 mouse (BCM) | SCGE Toolkit
Ai9 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt (ROSA)26Sor locus. This …
Systemic nanoparticle delivery of CRISPR-Cas9 ... - Nature
2020年6月26日 · To examine in vivo gene editing, we delivered 5A2-DOT-10 encapsulating Cas9/sgTOM complexes to the Td-Tomato mouse (Ai9 mouse) model (Fig. 3a). The …
Model Systems | SCGE Toolkit
Model Systems are cells and animals of particular species (e.g., mouse, pig, human cultured cells) that substitute for humans in research for developing and understanding safe …
Ai9 - Addgene
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain.
A comparative evaluation of the strengths and potential caveats of …
Comparing recombination in mice with the Ai9 versus the R26-YFP recombination reporter, we observed significantly fewer recombined IBA1 + brain macrophages in Tmem119 CreER and …
Generation of a Spiral Ganglion Neuron Degeneration Mouse Model
2021年10月26日 · The mouse model reported in this study may prove to be a powerful mammalian model to investigate the development of postnatal SGNs, degeneration of SGNs, …