2020年6月18日 · ATP has frequently been used to produced AF in pigs, which can develop quickly 1 to 7 days after initiation of ATP. 175,176 Importantly, pigs easily develop systolic …

2023年11月27日 · In our pig model, AF episodes were short, self-limiting and induced by burst pacing, probably best representing patients at risk of developing paroxysmal AF. Whether …

Previous animal models of AF require a chronic intervention to make AF reliably inducible. Our objective was to create an acute, reliable, and reproducible porcine model of sustained AF. To …

2017年7月15日 · Atrial fibrillation (AF) is associated with fibrosis that slows electrical conduction and causes perpetuation of the arrhythmia. The molecular characterization of AF …

2020年5月4日 · Here we investigated a pig model which reliably mimics the human phenotype of ischaemic heart failure 30 days after an ischaemia-reperfusion injury causing distinct atrial …

2015年3月16日 · AF was induced in domestic pigs by atrial burst pacing. The animals underwent electrophysiologic and echocardiographic examinations. Ca 2+ handling proteins were …

2012年2月1日 · We demonstrate successful and robust genetic suppression of AF in pigs. Application of an adenovirus encoding the long QT syndrome mutant CERG-G627S …

2020年4月9日 · AF pigs were tachypaced for 43 ± 4 days until in sustained AF. Functional remodeling was investigated by echocardiography (after cardioversion to sinus rhythm). …

2017年7月15日 · We hypothesized that HDAC2-dependent remodeling of KCNN2 and KCNN3 expression contributes to atrial arrhythmogenesis in AF complicated by HF. The objectives …

2020年6月19日 · Herein, we review the vast array of AF models available, spanning the mouse heart (weighing 1/1000th of a human heart) to the horse heart (10× heavier than the human …