The adventitia (/ æ d v ɛ n ˈ t ɪ ʃ ə / ad-ven-TI-shuh) is the outer layer of fibrous connective tissue surrounding an organ. [1] The outer layer of connective tissue that surrounds an artery, or vein – the tunica externa, is also called the tunica adventitia.

2017年12月24日 · The main difference between serosa and adventitia is that serosa covers the organs in the body cavities whereas adventitia attaches the organ to the surrounding tissues. The outermost layer of the serosa secretes the serous fluid, which lubricates the organs in …

2024年3月18日 · The term adventitia can typically refer to the outermost layer of the blood vessel wall or the outer connective tissue layer of organs devoid of mesothelium, that blends into the surrounding tissues. In relation to blood vessels, the adventitia is sometimes called the tunica adventitia or tunica externa .

The vascular adventitia acts as a biological processing center for the retrieval, integration, storage, and release of key regulators of vessel wall function. It is the most complex compartment of the vessel wall and is comprised of a variety of ...

The specific role of the adventitia and the adventitial fibroblast in the oxidant-antioxidant imbalance in pulmonary hypertension will be important both to understand the pathogenesis of vascular remodeling and potentially to develop novel therapeutic approaches.

In the late fetal and early neonatal period, the adventitia exhibits strong expression of sonic hedgehog signaling reporters (patched-1, patched-2, gli-1) that are colocalized with AdvSca1 progenitor cells. 1,11 In a study investigating the role of hedgehog signaling in a transgenic mouse model of pancreatic cancer, Tian et al reported finding ...

2022年11月1日 · The adventitia has been described as a master regulator of artery wall physiology and disease because it acts as an information processing center that communicates between the artery wall itself on one side and the immune system, the nervous system, locally-derived adipokines and microvascular cells on the other side to coordinate essential ...

2011年7月1日 · Recent studies show that the adventitia functions as a dynamic compartment for cell trafficking into and out of the artery wall, it participates in growth and repair of the vessel wall, and it mediates communication between vascular endothelial cells and smooth muscle cells (SMCs) and their local tissue environment (Figure 1B). 1 – 3 The ...

2015年8月1日 · It is now becoming clear that signals originating from within the adventitia and from perivascular cells play essential roles in regulation of vascular development, physiology, artery wall remodeling, immune surveillance, and vascular disease. 1 – 4 The adventitia is in contact with and completely surrounds the media and is the interface ...

The adventitia is resistant to the IA causing atherosclerosis, and it prevents the destructive process from eroding outward through the arterial wall into the pericardial space. The adventitia thickens and acts to maintain wall integrity as well as to confine the IA to the intima, where the only outlet for the necrotic core is into the artery ...