通过聚腺苷二磷酸核糖聚合酶(PARP)家族成员形成聚腺苷二磷酸核糖(ADP-ribose)时，腺苷5′-二磷酸核糖(ADP-Ribose)用作底物的基础嵌段。 聚腺苷酸核糖的形成和降解是脱氧核糖核酸修复和凋亡信号的重要组成部分。

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly (ADP-ribose) by members of the poly (ADP-ribose) polymerase (PARP) family. Poly (ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling.

Anti-pan-ADP-ribose binding reagent is useful for the affinity detection of both mono- and poly-ADP-ribosylated proteins on membranes in a manner similar to antibody-based Western and dot blot analysis, The rabbit Fc tag allows visualization of the binding with conjugated anti-rabbit secondary antibodies.

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for...

Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca 2+ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants.

Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that cleaves ribose-ribose bonds. This ZooMAb ® recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and …

Anti-mono-ADP-ribose binding reagent is a His-tagged recombinant protein fused to rabbit Fc tag, expressed in and purified from Rosetta (DE3)pLysS strain of E. coli (Cat. No. 70956). It is useful for the affinity detection of both mono-ADP-ribosylated proteins on membranes in a manner similar to antibody-based Western and dot blot analysis.

抗单ADP-核糖结合试剂，目录号MABE1076，是一种靶向单（ADP-核糖）修饰蛋白的试剂，已在斑点印迹和蛋白质印迹中进行了检验。 蛋白质印迹分析：0.4 µg/mL的代表性批次检测到单ADP-核糖基化蛋白。 斑点印迹分析：一个代表性批次检测到单-、-ADP-核糖修饰的蛋白质。 斑点印迹分析：一个代表性批次检测到单ADP核糖基化蛋白。 （由University of Texas Southwestern Medical Center的Lee Kraus提供）。 蛋白印迹分析: 一个代表性批次通过蛋白质印迹法检测到单ADP- …

The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. This PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers …

2021年12月20日 · We developed several molecular tools that are easy to produce and aid in the setup of high-throughput screening assays for a wide range of hydrolyzing and non-hydrolyzing ADP-ribosyl binding proteins. Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways or viral infections, making them attractive drug targets.