TREM2 — a key player in microglial biology and Alzheimer …
2018年9月28日 · In this Review, we focus on a receptor known as triggering receptor expressed on myeloid cells 2 (TREM2), which promotes the optimal microglial function required to …
TREM2 risk variants and associated endophenotypes in …
2025年3月6日 · Rare TREM2 variants are strong risk factors for Alzheimer’s disease (AD) [1,2,3,4,5,6].The triggering receptor expressed on myeloid cell 2 (TREM2) gene is situated on …
Higher plasma soluble TREM2 correlates with reduced cerebral …
2025年4月1日 · Loss-of-function mutation of triggering receptor expressed on myeloid cell 2 (TREM2) is associated with increased risks for Alzheimer’s disease (AD). Recent animal …
Enhancing TREM2 expression activates microglia and modestly …
2025年3月23日 · TREM2, a microglia-specific receptor, is strongly associated with Alzheimer’s disease (AD) risk, mediating microglial responses to amyloid pathology critical to AD …
开年3篇Nature！免疫靶点TREM2：拿下CNS、肥胖、 - 健康界
2023年2月3日 · Denali Therapeutics和武田公司开发了一种能够激活TREM2受体的抗体DNL919（ATV：TREM2），通过静脉注射给药，有望改善TREM2这一关键大脑免疫基因的 …
New insights into the role of TREM2 in Alzheimer’s disease
2018年12月20日 · These findings advance our understanding of TREM2 involvement in the response of microglia to Aβ aggregation and its consequences and strongly encourage …
TREM2 in the pathogenesis of AD: a lipid metabolism regulator …
2022年6月3日 · Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and …
A TREM2-activating antibody with a blood–brain barrier transport ...
2023年1月12日 · Here we describe a high-affinity human TREM2-activating antibody engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody transport vehicle …
A systematic review of the role of TREM2 in Alzheimer’s disease
2025年3月25日 · Background::Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer’s disease (AD), an expanding research …
The Therapeutic Potential of ADSC-Secreted LEFTY2 in Treating
4 天之前 · TREM2, a receptor expressed on microglia, has been recognized for its protective role in AD, enhancing microglial activity, promoting the clearance of Aβ, and attenuating Tau …