2025年3月30日 · ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Diseases associated with ACOT1 include Aztreonam Allergy and Cefaclor Allergy. Among its related pathways are Fatty acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and obsolete palmitoyl-CoA hydrolase activity.

Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene. [5] The ACOT1 gene is located on the 14th chromosome, with its specific localization being 14q24.3. It contains 7 exons. [5] The protein encoded by this gene contains 410 amino acids, and forms a homodimer with another chain. [6] .

Hepatic acyl-CoA thioesterase 1 (ACOT1) catalyzes the conversion of acyl-CoAs to fatty acids (FAs) and CoA. We sought to determine the role of ACOT1 in hepatic lipid metabolism in C57Bl/6J male mice 1 week after adenovirus-mediated Acot1 knockdown.

研究结果显示：Acot1可改善糖尿病心脏舒张功能不全，并通过减轻内质网应激，改善心脏炎症，进一步改善心脏病理重塑；Acot2可改善高脂诱导的心肌细胞氧化应激反应，从而减轻心肌细胞胰岛素抵抗，进而改善心脏舒张功能不全；此外，我们意外地发现Acot2靶向 ...

Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

2020年9月15日 · Acyl-CoA thioesterase 1 (Acot1), as an important enzyme in fatty acid metabolism, catalyzes the reaction of fatty acyl-CoAs to CoA-SH and free fatty acids 11....

2025年2月8日 · Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as highly absent genes in gastric cancer population. Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication. The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human ...

2007年8月1日 · The cytosolic acyl-coenzyme A thioesterase I (Acot1) is an enzyme that hydrolyzes long-chain acyl-CoAs of C 12-C 20-CoA in chain length to the free fatty acid and CoA. Acot1 was shown previously to be strongly upregulated at the mRNA and protein level in …

ACOT1 is a cytosolic enzyme with substrate selectivity for long chain (C12–C20) saturated-and monounsaturated acyl-CoAs. It is expressed mainly in liver, kidney, lung and heart in mouse [11, 16].

We identified seven DARs including a candidate enhancer for the ACOT1 gene that regulates the balance of acyl-CoA and free fatty acids (FFAs) in the cytoplasm. The relevance of ACOT1 regulation in T2D was supported by the analysis of transcriptomics and …