2025年3月30日 · ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Diseases associated with ACKR1 include White Blood Cell Count Quantitative Trait Locus 1 and Malaria. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

2025年1月10日 · 非典型趋化因子受体（ACKR）成员 ACKR1/DARC：由红细胞、内皮细胞和胎盘滋养层细胞表达。 血管内皮细胞上表达的ACKR1能够诱导趋化因子在血管内皮细胞管腔表面的聚集，从而增加白细胞渗出。 而红细胞上表达的ACKR1则能够调节循环趋化因子浓度的变化。

Atypical chemokine receptor 1 (ACKR1), previously known as the Duffy antigen receptor for chemokines (DARC), is a key regulator that binds chemokines involved in inflammatory responses and cancer proliferation, angiogenesis, and metastasis.

2024年12月22日 · ACKR1作为非典型性趋化因子受体蛋白，具有与多种趋化因子结合的独特能力，促进它们的清除或穿胞作用。 基因功能分析揭示了ACKR1hiECs对于白细胞跨越血管壁的迁移至关重要，强调了ACKR1在炎症反应中的作用。

1）非典型趋化因子受体1（ACKR1）： ACKR1结合主要作用于中性粒细胞和单核细胞的簇化趋化因子，以及CXCL11、CXCL12、CXCL9、CXCL10和CXCL13。

2025年3月26日 · Gene target information for ACKR1 - atypical chemokine receptor 1 (Duffy blood group) (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2013年10月11日 · ACKR1 can hetero-oligomerize with CC-chemokine receptor 5 (CCR5) in transfected immortalized cells to impair CCR5-driven signalling and chemotaxis (Fig. 2d), and ACKR1 and CCR5 can be...

2024年11月18日 · We found that many signalling proteins produced by certain cell types interacted strongly with a protein called ‘ACKR1’. Other investigations showed that high levels of ACKR1 aggravated skin fibrosis. Finally, ‘macrophages’ (a type of white blood cell) that produced high levels of two different proteins caused skin fibrosis to worsen.

2024年9月24日 · Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

2024年5月7日 · ACKR1 recognizes a range of inflammatory chemokines from both the CXC chemokine and CC chemokine subfamilies, including for example the potent neutrophil chemoattractant CXCL8 and the mononuclear...