2025年3月28日 · ACAA1 (Acetyl-CoA Acyltransferase 1) is a Protein Coding gene. Diseases associated with ACAA1 include Immunodeficiency 68 and Chondrodysplasia Punctata Syndrome. Among its related pathways are Peroxisomal lipid metabolism and Fatty acid metabolism.

Acetyl-Coenzyme A acyltransferase 1 is an acetyl-CoA C-acyltransferase enzyme. This gene encodes an enzyme operative in the beta oxidation system of the peroxisomes. [5] Deficiency of this enzyme leads to pseudo- Zellweger syndrome. [5] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

2002年3月1日 · Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (Probable). Plays an important role in fatty acid peroxisomal beta-oxidation (Probable). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (By similarity). This reaction proceeds in the backward direction.

View mouse Acaa1b Chr9:118977111-118986149 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

High impact information on Acaa1b. Hence, to better understand the cause of isolated human thiolase deficiency, we disrupted the catalytic site of the mouse thiolase B by homologous recombination in order to analyse the phenotype of these thiolase B-deficient mice .

Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Located in peroxisome.

Mus musculus complex locus Acaa1b, encoding acetyl-Coenzyme A acyltransferase 1B.

Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity).

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235674 (Acaa1b) 00592 alpha-Linolenic acid metabolism 235674 (Acaa1b) 01040 Biosynthesis of unsaturated fatty acids 235674 (Acaa1b) 09105 Amino acid metabolism 00280 Valine, leucine and isoleucine degradation 235674 (Acaa1b) 09140 Cellular Processes 09141 Transport and catabolism 04146 Peroxisome 235674 (Acaa1b) Enzymes [BR:mmu01000] 2 ...