004191 B6.Cg- Immp2l Tg(HLA-A/H2-D)2Enge /J AAD transgenic mice express an interspecies hybrid class I MHC gene, AAD, which contains the alpha-1 and alpha-2 domains of the human HLA-A2.1 gene and the alpha-3 transmembrane and cytoplasmic domains of the mouse H-2D d gene/allele, under the direction of the human HLA-A2.1 promoter.

2021年2月4日 · In this study, we investigated the utility of contrast-enhanced CT with a nanoparticle contrast agent for the early detection of aortic injury in a mouse model of sporadic AAD. We show that CTD enabled the detection of aortic wall degeneration associated with various stages of disease severity.

2022年1月1日 · BAPN-induced AAD replicates a spectrum of the features of human AAD (Table II). Thus, this mouse model provides opportunities to study the complex mechanisms of AAD from the early to advanced stages for exploring potential therapies.

2022年12月12日 · Our current study aims to establish a reliable, time and cost-effective mouse AD model. To conduct the meta-analysis, we searched PubMed for related studies up to 2021 and statistical analysis...

2022年11月12日 · Moxifloxacin (MFLX) induced AAD formation in mice with moderate-severity AAD. MFLX decreased SM22α expression in the tissues of mice with AAD. MFLX increased the protein expression of OPN and MMP-2 in tissues of mice with AAD.

2024年9月9日 · Acute aortic dissection (AAD) is a serious disease in which the largest artery in the body, called the aorta, enlarges and ruptures. Surgery is often required to...

Acute aortic dissection (AAD) progresses rapidly and is associated with high mortality; therefore, there remains an urgent need for pharmacological agents that can protect against AAD. Herein, we examined the therapeutic effects of cannabidiol (CBD) in AAD by establishing a …

Treatment of ovariectomized mice with estradiol protected AAD formation (p = .014). In summary, this study developed a powerful mouse AAD model that can be used to study the sexual dimorphism in AAD formation.

2023年3月23日 · Clinical data of patients with AAD and healthy controls were collected, and the level of the cystathionine γ lyase (CSE)/hydrogen sulfide (H 2 S) system in plasma and aortic tissue were determined. Mice with EC-specific CSE deletion or overexpression were generated, and the progression of AAD was determined.

2025年3月27日 · SMC-specific PDE5A knockout (PDE5A SMC−/−) and PDE5A-overexpressing (PDE5A SMC-OE) mice were constructed and utilized, along with an AAD mouse model induced by a high-fat diet and angiotensin II (Ang II) infusion. In vivo imaging and histological analyses were performed to assess aortic pathologies. PDE5A expression was reduced in human and ...