ATR抑制剂：点燃合成致死靶点新希望 - 知乎 - 知乎专栏
ATR抑制剂 一度被认为是继 PARP抑制剂 后最有希望的 合成致死靶点 之一，为 ATM突变 患者新的治疗药物。 ATR在DNA损伤后能够激活细胞应答，进而阻滞细胞周期进程并稳定复制叉及 …
Targeting ATR in patients with cancer - Nature
2024年2月20日 · Currently available data from clinical trials of single-agent ATR inhibitors have revealed an emerging efficacy signal in patients with ovarian cancers resistant to platinum …
The ATR inhibitor ceralasertib potentiates cancer checkpoint ...
2024年2月24日 · The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in …
ATR inhibition activates cancer cell cGAS/STING-interferon
2024年9月27日 · The ATR kinase inhibitor, ceralasertib, generates consistent antitumor responses in two distinct and unique immunocompetent mouse models of SCLC. In addition, …
Targeting ATR in cancer - Nature Reviews Cancer
2018年6月13日 · With ATR inhibitors now entering clinical trials, we here revisit the biology behind this strategy and discuss potential biomarkers that could be used for a better selection of …
Progress towards a clinically-successful ATR inhibitor for cancer ...
Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated significant therapeutic potential in cancer treatment, with …
Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor ...
2024年12月4日 · Ataxia telangiectasia and Rad3-related protein (ATR) is a key regulator of the DDR machinery and an attractive therapeutic target, with multiple ATR inhibitors holding …
ATR Inhibition as an Attractive Therapeutic Resource against Cancer
2021年1月6日 · In this issue of Cancer Discovery, Yap and colleagues demonstrate in a phase I trial enrolling 22 patients diagnosed with advanced solid tumors that BAY 1895344, a new …
ATR抑制剂抗肿瘤治疗的研究新进展 - cjco.cn
Several potent, selective ATR inhibitors have been developed. Here, we summarize the clinical trial data supporting the application of ATR inhibitors for anticancer therapy, as single agents …
ATR Inhibitor: Mechanism, Classes, and Research Trends
2025年3月19日 · ATR inhibitors are a growing area of interest in cancer research, offering potential for enhancing DNA-damaging therapies. ATR (ataxia telangiectasia and Rad3 …