CHK1促进CDC25A的蛋白酶体降解，可以降低CDK（细胞周期蛋白依赖性激酶）活性，抑制细胞周期进程，为DNA修复争取时间。 CHK1还通过 BRCA1 、 BRCA2 和RAD51的磷酸化促 …

In addition, suppressing DNA damage and replication checkpoint responses by inhibiting Chk1 can enhance tumor cell killing by diverse genotoxic agents. Here, we review current …

2022年12月16日 · chk1抑制剂被证明可以增强dna损伤药物如吉西他滨、顺铂在p53缺失癌细胞中的细胞毒作用。 与ATR抑制剂类似，CHK1抑制剂加剧了PARP抑制引起的DNA损伤。 此 …

最新的观点认为CHK1是DNA损伤应答激活的主要标志物，表明CHK1不仅激活了细胞周期检查位点的调节，而且直接影响了DNA修复和细胞凋亡。 因此CHK1在DNA损伤应答机制中的作用能够 …

Upon activation, ATR can phosphorylate downstream targets including Chk1. ATR-mediated Chk1 phosphorylation also requires another intermediate protein called claspin, which binds and …

This review article describes the role of ATR and its major downstream target, CHK1, in the DDR and why cancer cells are particularly reliant on the ATR-CHK1 pathway, providing the rationale …

2024年10月1日 · In this study, we identify an ATR and Chk1 interacting lncRNA (ACIL, also known as LRRC75A-AS1 or SNHG29), which promotes the phosphorylation of Chk1 by ATR …

Chk1 is an evolutionarily conserved protein kinase that regulates cell cycle progression in response to checkpoint activation. In this study, we demonstrated that agents that block DNA …

Here, we review the status of the development of ATR and CHK1 inhibitors. We also discuss the potential mechanisms by which ATR and CHK1 inhibition induces cell killing in the presence or …

2018年3月1日 · ATR/CHK1 inhibitors have been developed and are currently used either as single agents or paired with radiotherapy or a variety of genotoxic chemotherapies in …